Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes

…, C Wooding, K Linton, DR Alexander… - Nature cell …, 2005 - nature.com
Phosphatidylserine (PS) exposure is normally associated with apoptosis and the removal of
dying cells. We observed that PS is exposed constitutively at high levels on T lymphocytes …

[PDF][PDF] The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses

…, M Roche-Molina, P Tandon, N Holmes, DR Alexander - Immunity, 2007 - cell.com
The molecular mechanisms whereby the CD45 tyrosine phosphatase (PTPase) regulates T
cell receptor (TCR) signaling responses remain to be elucidated. To investigate this question…

The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function

DR Alexander - Seminars in immunology, 2000 - Elsevier
The CD45 phosphotyrosine phosphatase is one of the most abundant glycoproteins expressed
on immune cells. Previously, the serpentine twists and turns of the CD45 research field …

CTLA-4 suppresses proximal TCR signaling in resting human CD4+ T cells by inhibiting ZAP-70 Tyr319 phosphorylation: a potential role for tyrosine phosphatases

C Guntermann, DR Alexander - The Journal of Immunology, 2002 - journals.aai.org
The balance between positive and negative signals plays a key role in determining T cell
function. CTL-associated Ag-4 is a surface receptor that can inhibit T cell responses induced …

The phosphotyrosine phosphatase SHP-2 participates in a multimeric signaling complex and regulates T cell receptor (TCR) coupling to the Ras/mitogen-activated …

JA Frearson, DR Alexander - The Journal of experimental medicine, 1998 - rupress.org
Src homology 2 (SH2) domain–containing phosphotyrosine phosphatases (SHPs) are
increasingly being shown to play critical roles in protein tyrosine kinase–mediated signaling …

[HTML][HTML] Inhibition of the Bcl-xL Deamidation Pathway in Myeloproliferative Disorders

…, BJP Huntly, AR Green, DR Alexander - … England Journal of …, 2008 - Mass Medical Soc
Background The myeloproliferative disorders are clonal disorders with frequent somatic gain-of-function
alterations affecting tyrosine kinases. In these diseases, there is an increase in …

Cutting edge: TREM-like transcript-1, a platelet immunoreceptor tyrosine-based inhibition motif encoding costimulatory immunoreceptor that enhances, rather than …

…, RW Farndale, DR Alexander… - The Journal of …, 2004 - journals.aai.org
To date, immunoreceptor tyrosine-based inhibition motifs (ITIMs) have been shown to mediate
inhibitory properties. We report a novel triggering receptor expressed on myeloid cells (…

[BOOK][B] Biology and ideology from Descartes to Dawkins

DR Alexander, RL Numbers - 2010 - books.google.com
Over the course of human history, the sciences, and biology in particular, have often been
manipulated to cause immense human suffering. For example, biology has been used to …

[HTML][HTML] Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal …

…, LK Goff, P Beverley, J Szollosi, DR Alexander - Journal of Biological …, 2002 - ASBMB
An investigation into the role of CD45 isoforms in T cell antigen receptor signal transduction
was carried out by transfecting CD45-negative CD4 + CD8 + HPB-ALL T cells with the …

The NPM-ALK tyrosine kinase mimics TCR signalling pathways, inducing NFAT and AP-1 by RAS-dependent mechanisms

…, D Yeung, K Hadfield, SJ Cook, DR Alexander - Cellular signalling, 2007 - Elsevier
Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) expression is associated with the
lymphoid malignancy anaplastic large cell lymphoma (ALCL) and results from at(2;5) …