User profiles for DAVID G. HUNTSMAN
David HuntsmanBC Cancer Agency Verified email at bccancer.bc.ca Cited by 103020 |
[HTML][HTML] ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
Background Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis,
but the molecular events involved in this transformation have not been described. Methods …
but the molecular events involved in this transformation have not been described. Methods …
Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer
…, J Galon, C Gourley, V Heong, DG Huntsman… - Nature reviews …, 2015 - nature.com
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article…
and overall survival has not changed significantly for several decades. In this Opinion article…
[HTML][HTML] Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies
…, PA Fasching, SA Gayther, DG Huntsman… - The lancet …, 2012 - thelancet.com
Background Endometriosis is a risk factor for epithelial ovarian cancer; however, whether
this risk extends to all invasive histological subtypes or borderline tumours is not clear. We …
this risk extends to all invasive histological subtypes or borderline tumours is not clear. We …
[HTML][HTML] Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary
Background Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian
sex cord–stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, …
sex cord–stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, …
Hereditary diffuse gastric cancer syndrome: CDH1 mutations and beyond
Importance E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting
clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates of cancer risk …
clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates of cancer risk …
Familial gastric cancer: overview and guidelines for management
…, SM Powell, FR Lewis, DG Huntsman… - Journal of medical …, 1999 - jmg.bmj.com
Families with autosomal dominant inherited predisposition to gastric cancer have been
described. More recently, germlineE-cadherin/CDH1mutations have been identified in hereditary …
described. More recently, germlineE-cadherin/CDH1mutations have been identified in hereditary …
MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
…, G Leung, SJ Jones, JM Connors, DG Huntsman… - Nature, 2011 - nature.com
Chromosomal translocations are critically involved in the molecular pathogenesis of B-cell
lymphomas, and highly recurrent and specific rearrangements have defined distinct …
lymphomas, and highly recurrent and specific rearrangements have defined distinct …
Confirmation of ProMisE: a simple, genomics‐based clinical classifier for endometrial cancer
BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is
irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive …
irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive …
[HTML][HTML] Cancer-associated mutations in endometriosis without cancer
Background Endometriosis, defined as the presence of ectopic endometrial stroma and
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain …
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain …
[HTML][HTML] Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations
DG Huntsman, F Carneiro, FR Lewis… - … England Journal of …, 2001 - Mass Medical Soc
Background Germ-line truncating mutations in the E-cadherin (CDH1) gene have been
found in families with hereditary diffuse gastric cancer. These families are characterized by a …
found in families with hereditary diffuse gastric cancer. These families are characterized by a …