User profiles for DAVID G. HUNTSMAN

David Huntsman

BC Cancer Agency
Verified email at bccancer.bc.ca
Cited by 103020

[HTML][HTML] ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

…, B Gilks, MA Marra, DG Huntsman - … England Journal of …, 2010 - Mass Medical Soc
Background Ovarian clear-cell and endometrioid carcinomas may arise from endometriosis,
but the molecular events involved in this transformation have not been described. Methods …

Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

…, J Galon, C Gourley, V Heong, DG Huntsman… - Nature reviews …, 2015 - nature.com
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article…

[HTML][HTML] Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case–control studies

…, PA Fasching, SA Gayther, DG Huntsman… - The lancet …, 2012 - thelancet.com
Background Endometriosis is a risk factor for epithelial ovarian cancer; however, whether
this risk extends to all invasive histological subtypes or borderline tumours is not clear. We …

[HTML][HTML] Mutation of FOXL2 in Granulosa-Cell Tumors of the Ovary

…, CB Gilks, M Marra, DG Huntsman - … England Journal of …, 2009 - Mass Medical Soc
Background Granulosa-cell tumors (GCTs) are the most common type of malignant ovarian
sex cord–stromal tumor (SCST). The pathogenesis of these tumors is unknown. Moreover, …

Hereditary diffuse gastric cancer syndrome: CDH1 mutations and beyond

…, C Oliveira, PDP Pharoah, DG Huntsman - JAMA …, 2015 - jamanetwork.com
Importance E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting
clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates of cancer risk …

Familial gastric cancer: overview and guidelines for management

…, SM Powell, FR Lewis, DG Huntsman… - Journal of medical …, 1999 - jmg.bmj.com
Families with autosomal dominant inherited predisposition to gastric cancer have been
described. More recently, germlineE-cadherin/CDH1mutations have been identified in hereditary …

MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers

…, G Leung, SJ Jones, JM Connors, DG Huntsman… - Nature, 2011 - nature.com
Chromosomal translocations are critically involved in the molecular pathogenesis of B-cell
lymphomas, and highly recurrent and specific rearrangements have defined distinct …

Confirmation of ProMisE: a simple, genomics‐based clinical classifier for endometrial cancer

…, M Anglesio, JS Kwon, AN Karnezis, DG Huntsman… - Cancer, 2017 - Wiley Online Library
BACKGROUND Classification of endometrial carcinomas (ECs) by morphologic features is
irreproducible and imperfectly reflects tumor biology. The authors developed the Proactive …

[HTML][HTML] Cancer-associated mutations in endometriosis without cancer

…, B Vogelstein, PJ Yong, DG Huntsman… - … England Journal of …, 2017 - Mass Medical Soc
Background Endometriosis, defined as the presence of ectopic endometrial stroma and
epithelium, affects approximately 10% of reproductive-age women and can cause pelvic pain …

[HTML][HTML] Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations

DG Huntsman, F Carneiro, FR Lewis… - … England Journal of …, 2001 - Mass Medical Soc
Background Germ-line truncating mutations in the E-cadherin (CDH1) gene have been
found in families with hereditary diffuse gastric cancer. These families are characterized by a …