There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection.
We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in …

We found that the cancerous pancreas harbors a markedly more abundant microbiome
compared with normal pancreas in both mice and humans, and select bacteria are differentially …

Neoplastic pancreatic epithelial cells are believed to die through caspase 8-dependent
apoptotic cell death, and chemotherapy is thought to promote tumour apoptosis 1 . Conversely, …

The transition of chronic pancreatic fibroinflammatory disease to neoplasia is a primary
example of the paradigm linking inflammation to carcinogenesis. However, the cellular and …

Cancer alters the function of multiple organs beyond those targeted by metastasis 1 , 2 .
Here we show that inflammation, fatty liver and dysregulated metabolism are hallmarks of …

The progression of pancreatic oncogenesis requires immune-suppressive inflammation in
cooperation with oncogenic mutations. However, the drivers of intratumoral immune tolerance …

Pancreatic ductal adenocarcinoma is an aggressive cancer that interacts with stromal cells
to produce a highly inflammatory tumor microenvironment that promotes tumor growth and …

Pancreatic cancer is one of the most lethal cancers worldwide. No effective screening methods
exist, and available treatment modalities do not effectively treat the disease. Inflammatory …

Nonalcoholic steatohepatitis (NASH) is the most common etiology of chronic liver dysfunction
in the United States and can progress to cirrhosis and liver failure. Inflammatory insult …

BACKGROUND & AIMS: Immune cells of the liver must be able to recognize and react to
pathogens yet remain tolerant to food molecules and other nonpathogens. Dendritic cells (DCs) …