Purpose: Glioblastoma (GBM) is the most common form of malignant glioma in adults.
Although protected by both the blood–brain and blood–tumor barriers, GBMs are actively …

ATG4B stimulates autophagy by promoting autophagosome formation through reversible
modification of ATG8. We identify ATG4B as a substrate of mammalian sterile20-like kinase (…

Aberrant activation of EGFR in human cancers promotes tumorigenesis through stimulation
of AKT signaling. Here, we determined that the discoidina neuropilin-like membrane protein …

Background Oncolytic adenoviral virotherapy (OV) is a highly promising approach for the
treatment of glioblastoma multiforme (GBM). In practice, however, the approach is limited by …

Neurotrophins protect neurons against excitotoxicity; however the signaling mechanisms for
this protection remain to be fully elucidated. Here we report that activation of the …

Glioblastoma multiforme (GBM) remains fatal despite intensive surgical, radiotherapeutic,
and chemotherapeutic interventions. Neural stem cells (NSCs) have been used as cellular …

In this study, we investigated the potential of combined treatment with temozolomide (TMZ)
chemotherapy and tumor antigen-pulsed dendritic cells (DCs) and the underlying …

Pellino-1 is an E3 ubiquitin ligase acting as a critical mediator for a variety of immune
receptor signaling pathways, including Toll-like receptors, interleukin-1 receptor and T-cell …

Skin aging appears to be the result of overlapping intrinsic (including genetic and hormonal
factors) and extrinsic (external environment including chronic light exposure, chemicals, and …

The ErbB3 binding protein Ebp1 has been implicated in a number of human cancers. Ebp1
includes 2 isoforms, p48 and p42, that exhibit different cellular activities. Here we show that …