User profiles for CHRISTOPHER G. KEVIL

Christopher Kevil

Vice Chancellor for Research and Professor at LSU Health Shreveport
Verified email at lsuhsc.edu
Cited by 15584

Hydrogen sulfide mediates cardioprotection through Nrf2 signaling

…, A Ramachandran, CB Pattillo, CG Kevil… - Circulation …, 2009 - Am Heart Assoc
Rationale: The recent emergence of hydrogen sulfide (H 2 S) as a potent cardioprotective
signaling molecule necessitates the elucidation of its cytoprotective mechanisms. Objective: …

[HTML][HTML] Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing

GK Kolluru, SC Bir, CG Kevil - International journal of vascular …, 2012 - hindawi.com
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate
hyperglycemia due to lack of or resistance to insulin. Patients with DM are frequently afflicted with …

[HTML][HTML] Nitrate and nitrite in biology, nutrition and therapeutics

…, M Frenneaux, J Friedman, M Kelm, CG Kevil… - Nature chemical …, 2009 - nature.com
Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to
nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is …

[HTML][HTML] Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver

…, RP Patel, SF Yet, X Wang, CG Kevil… - The Journal of …, 2005 - Am Soc Clin Investig
Nitrite represents a circulating and tissue storage form of NO whose bioactivation is mediated
by the enzymatic action of xanthine oxidoreductase, nonenzymatic disproportionation, and …

[HTML][HTML] Hydrogen sulfide chemical biology: pathophysiological roles and detection

GK Kolluru, X Shen, SC Bir, CG Kevil - Nitric oxide, 2013 - Elsevier
Hydrogen sulfide (H 2 S) is the most recent endogenous gasotransmitter that has been reported
to serve many physiological and pathological functions in different tissues. Studies over …

Measurement of plasma hydrogen sulfide in vivo and in vitro

…, S Pardue, SC Bir, R Wang, CG Kevil - Free Radical Biology …, 2011 - Elsevier
The gasotransmitter hydrogen sulfide is known to regulate multiple cellular functions during
normal and pathophysiological states. However, a paucity of concise information exists …

[HTML][HTML] Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins

CG Kevil, DK Payne, E Mire, JS Alexander - Journal of Biological Chemistry, 1998 - ASBMB
Vascular permeability factor/vascular endothelial growth factor stimulates endothelial
proliferation, angiogenesis, and increased vascular permeability in vivo . We investigated …

[PDF][PDF] Macrophage metabolism of apoptotic cell-derived arginine promotes continual efferocytosis and resolution of injury

…, BD Gerlach, Z Zheng, G Kuriakose, CG Kevil… - Cell metabolism, 2020 - cell.com
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis
and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we …

Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis

…, X Teng, DJ Lefer, RP Patel, CG Kevil - Proceedings of the …, 2008 - National Acad Sciences
Chronic tissue ischemia due to defective vascular perfusion is a hallmark feature of peripheral
artery disease for which minimal therapeutic options exist. We have reported that sodium …

H2O2-mediated permeability: role of MAPK and occludin

CG Kevil, T Oshima, B Alexander… - … of Physiology-Cell …, 2000 - journals.physiology.org
H 2 O 2 -mediated elevation in endothelial solute permeability is associated with pathological
events such as ischemia-reperfusion and inflammation. To understand how H 2 O 2 …