Human UDP-glucuronosyltransferases: metabolism, expression, and disease

RH Tukey, CP Strassburg - Annual review of pharmacology and …, 2000 - annualreviews.org
In vertebrates, the glucuronidation of small lipophilic agents is catalyzed by the endoplasmic
reticulum UDP-glucuronosyltransferases (UGTs). This metabolic pathway leads to the …

Portopulmonary hypertension and hepatopulmonary syndrome

MM Hoeper, MJ Krowka, CP Strassburg - The Lancet, 2004 - thelancet.com
The clinically and pathophysiologically distinct entities of portopulmonary hypertension and
hepatopulmonary syndrome occur in a substantial proportion of patients who have …

Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis

…, F Szalay, M Färkkilä, M Pröls, CP Strassburg… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Autoimmune hepatitis (AIH) is a chronic liver disease associated
with cirrhosis and liver failure. Corticosteroid therapy induces long-term remission but has …

Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis

…, TH Karlsen, E Schrumpf, CP Strassburg… - Gastroenterology, 2017 - Elsevier
Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary
disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of …

[PDF][PDF] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19

…, G Hack, C Finnemann, HD Nischalke, CP Strassburg… - Immunity, 2021 - cell.com
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…

[HTML][HTML] Expression of the UDP-glucuronosyltransferase 1A locus in human colon: identification and characterization of the novel extrahepatic UGT1A8

CP Strassburg, MP Manns, RH Tukey - Journal of Biological Chemistry, 1998 - ASBMB
UDP-glucuronosyltransferases (UGT) catalyze the conjugation of lipophilic exobiotic and
endobiotic compounds, which leads to the excretion of hydrophilic glucuronides via bile or urine…

Differential Expression of the UGT1A Locus in Human Liver, Biliary, and Gastric Tissue: Identification ofUGT1A7 and UGT1A10 Transcripts in Extrahepatic Tissue

CP Strassburg, K Oldhafer, MP Manns, RH Tukey - Molecular pharmacology, 1997 - ASPET
Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts
the existence of at least nine individual proteins. The different proteins are generated by …

Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

…, D Eulberg, T Luedde, G Marx, CP Strassburg… - Hepatology, 2016 - journals.lww.com
Acetaminophen (APAP, paracetamol) poisoning is a leading cause of acute liver failure (ALF)
in humans and induces hepatocyte necrosis, followed by activation of the innate immune …

[PDF][PDF] Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis

A Vogel, CP Strassburg, MP Manns - Hepatology, 2002 - Wiley Online Library
Autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC) are immune‐mediated
chronic inflammatory diseases of the liver of unknown etiology. Genetic factors appear to be …

[PDF][PDF] Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury

…, X Volkmann, C Poremba, CP Strassburg… - …, 2004 - Wiley Online Library
Chronic hepatitis C virus (HCV) infection is characterized by inflammatory liver damage and
is associated with a high risk of development of cirrhosis and hepatocellular carcinoma. …