Peripheral PD1-positive CD4 T-lymphocyte count can predict progression-free survival in patients with non-small cell lung cancer receiving immune checkpoint …

…, T Kado, S Okazawa, S Imanishi, C Taka… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: Little information is available about the association between peripheral T-lymphocyte
expression of programmed cell death protein 1 (PD1) and the efficacy of immune …

[HTML][HTML] Peripheral CD4 memory T cells predict the efficacy of immune checkpoint inhibitor therapy in patients with non-small cell lung cancer

…, K Hayashi, Z Seto, T Hirai, K Tokui, C Taka… - Scientific Reports, 2023 - nature.com
Immune checkpoint inhibitors have significantly improved the prognosis in patients with non-small
cell lung cancer, compared with cytotoxic agents. However, the prediction of treatment …

SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients

C Taka, R Hayashi, K Shimokawa, K Tokui… - … Journal of Chronic …, 2017 - Taylor & Francis
Background Physical activity (PA) is considered as one of the most important prognostic
predictors in chronic obstructive pulmonary disease (COPD) patients. Longevity gene, SIRT1, is …

[HTML][HTML] Elevated levels of plasma lactate dehydrogenase is an unfavorable prognostic factor in patients with epidermal growth factor receptor mutation‑positive non …

…, K Shimokawa, K Tokui, C Taka… - Molecular and …, 2016 - spandidos-publications.com
Abstract Treatment with epidermal growth factor receptor‑tyrosine kinase inhibitors (EGFR‑TKIs)
has been shown to prolong survival in patients with EGFR mutation‑positive non‑small …

Clinical parameters for predicting the survival in patients with squamous and non-squamous-cell NSCLC receiving PD-1 inhibitor therapy

M Inomata, T Hirai, Z Seto, K Tokui, C Taka… - Pathology & Oncology …, 2020 - Springer
We explored the associations between progression-free survival (PFS) after the initiation of
PD-1 inhibitor therapy and the clinical parameters in patients with NSCLC. We reviewed the …

[HTML][HTML] Plasma neuron-specific enolase level as a prognostic marker in patients with non-small cell lung cancer receiving gefitinib

…, A Yamamoto, K Tokui, C Taka… - Molecular and …, 2015 - spandidos-publications.com
Determination of the presence of epidermal growth factor receptor (EGFR) gene mutation is
useful for predicting the efficacy of gefitinib. However, the survival rate following the initiation …

Association of serum adiponectin with asthma and pulmonary function in the Japanese population

…, M Inomata, Y Kawagishi, K Tokui, C Taka… - Endocrine …, 2015 - jstage.jst.go.jp
Conflicting findings have been reported regarding the role of adiponectin in asthma. The aim
of this study was to evaluate the association of adiponectin with pulmonary functions and …

[HTML][HTML] Association of tumor PD-L1 expression with the T790M mutation and progression-free survival in patients with EGFR-mutant non-small cell lung cancer …

…, K Azechi, N Takata, K Hayashi, K Tokui, C Taka… - Diagnostics, 2020 - mdpi.com
Background: Among patients with non-small cell lung cancer (NSCLC), we compared the
progression-free survival (PFS) and proportion of acquisition of T790M mutation of the …

Outcome and prognostic factors in patients with small cell lung cancer who receive third-line chemotherapy

M Inomata, R Hayashi, K Tokui, C Taka… - Tumori …, 2014 - journals.sagepub.com
Aims and Background It is reported that about 20% of patients with small cell lung cancer (SCLC)
receive third-line chemotherapy. We conducted a retrospective study to investigate the …

Efficacy of immune checkpoint inhibitor therapy in patients with pulmonary sarcomatoid carcinoma in clinical practice

…, T Hirai, Z Seto, K Tokui, Y Masaki, C Taka… - Thoracic …, 2023 - Wiley Online Library
Objective Studies have suggested the potential efficacy of immune checkpoint inhibitors (ICIs)
for pulmonary sarcomatoid carcinoma. This multicenter observational study was …