Emerging strategies of cancer therapy based on ferroptosis

Z Shen, J Song, BC Yung, Z Zhou, A Wu… - Advanced …, 2018 - Wiley Online Library
Ferroptosis, a new form of regulated cell death that is iron‐ and reactive oxygen species
dependent, has attracted much attention in the research communities of biochemistry, oncology, …

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

X Huang, J Song, BC Yung, X Huang… - Chemical Society …, 2018 - pubs.rsc.org
Exploring and understanding biological and pathological changes are of great significance
for early diagnosis and therapy of diseases. Optical sensing and imaging approaches have …

Toxic reactive oxygen species enhanced synergistic combination therapy by self‐assembled metal‐phenolic network nanoparticles

…, BC Yung, R Tian, O Jacobson, C Xu… - Advanced …, 2018 - Wiley Online Library
Engineering functional nanomaterials with high therapeutic efficacy and minimum side
effects has increasingly become a promising strategy for cancer treatment. Herein, a reactive …

Stimuli‐responsive NO release for on‐demand gas‐sensitized synergistic cancer therapy

W Fan, BC Yung, X Chen - Angewandte Chemie International …, 2018 - Wiley Online Library
Featuring high biocompatibility, the emerging field of gas therapy has attracted extensive
attention in the medical and scientific communities. Currently, considerable research has …

Repurposing cyanine NIR‐I dyes accelerates clinical translation of near‐infrared‐II (NIR‐II) bioimaging

S Zhu, Z Hu, R Tian, BC Yung, Q Yang… - Advanced …, 2018 - Wiley Online Library
The significantly reduced tissue autofluorescence and scattering in the NIR‐II region (1000–1700
nm) opens many exciting avenues for detailed investigation of biological processes in …

[HTML][HTML] Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy

…, R Tian, Q Ni, S Cheng, Z Wang, N Lu, BC Yung… - Nature …, 2017 - nature.com
Subunit vaccines have been investigated in over 1000 clinical trials of cancer immunotherapy,
but have shown limited efficacy. Nanovaccines may improve efficacy but have rarely been …

[HTML][HTML] A discrete organoplatinum (II) metallacage as a multimodality theranostic platform for cancer photochemotherapy

…, S Yu, ML Saha, J Zhou, TR Cook, BC Yung… - Nature …, 2018 - nature.com
Photodynamic therapy is an effective alternative to traditional treatments due to its minimally
invasive nature, negligible systemic toxicity, fewer side effects, and avoidance of drug …

[HTML][HTML] Near-infrared-II (NIR-II) bioimaging via off-peak NIR-I fluorescence emission

S Zhu, BC Yung, S Chandra, G Niu, AL Antaris… - Theranostics, 2018 - ncbi.nlm.nih.gov
Significantly reduced photon scattering and minimal tissue autofluorescence levels in the
second biological transparency window (NIR-II; 1000-1700 nm) facilitate higher resolution in …

[HTML][HTML] Intertwining DNA-RNA nanocapsules loaded with tumor neoantigens as synergistic nanovaccines for cancer immunotherapy

…, O Jacobson, Z Wang, Y Liu, BC Yung… - Nature …, 2017 - nature.com
Nanomedicines that co-deliver DNA, RNA, and peptide therapeutics are highly desirable
yet remain underdeveloped for cancer theranostics. Herein, we report self-assembled …

[HTML][HTML] Polyrotaxane-based supramolecular theranostics

G Yu, Z Yang, X Fu, BC Yung, J Yang, Z Mao… - Nature …, 2018 - nature.com
The development of smart theranostic systems with favourable biocompatibility, high
loading efficiency, excellent circulation stability, potent anti-tumour activity, and multimodal …