Background Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its
susceptibility locus has been mapped to 17q25.3 in Japanese families, but the susceptibility …

Saccular intracranial aneurysms are balloon-like dilations of the intracranial arterial wall;
their hemorrhage commonly results in severe neurologic impairment and death. We report a …

RNA polymerase II mediates the transcription of all protein-coding genes in eukaryotic cells,
a process that is fundamental to life. Genomic mutations altering this enzyme have not …

Gliomas represent approximately 30% of all central nervous system tumors and 80% of
malignant brain tumors 1 . To understand the molecular mechanisms underlying the malignant …

Object While the use of endoscopic approaches has become increasingly accepted in the
resection of pituitary adenomas, limited evidence exists regarding the success of this …

Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or
malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, …

The pathogenesis of intracranial aneurysm (IA) formation and rupture is complex, with
significant contribution from genetic factors. We previously reported genome-wide association …

Object Several studies have revealed that the gross-total resection (GTR) of malignant brain
tumors has a significant influence on patient survival. Frequently, however, GTR cannot be …

Schwannomas are common peripheral nerve sheath tumors that can cause debilitating
morbidities. We performed an integrative analysis to determine genomic aberrations common to …

OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape
of meningiomas, identifying somatic coding alterations in NF2 , SMARCB1 , SMARCE1 , …