Background Acute respiratory distress syndrome is characterized by damage to the lung
caused by various insults, including ventilation itself, and tidal hyperinflation can lead to …

Objective: To determine the impact of renal biomarker–guided implementation of the Kidney
Disease Improving Global Outcomes (KDIGO) care bundle on the incidence of acute kidney …

Skeletal muscle toxicity is a rare and uncommon side effect of local anesthetic drugs.
Intramuscular injections of these agents regularly result in reversible myonecrosis. The extent of …

AIM OF THE STUDY: Death to trauma is caused by disastrous injuries on scene, bleeding
shock or acute respiratory failure (ARDS) induced by trauma and massive blood transfusion. …

Background Ropivacaine is believed to have a lower incidence of clinical cardiac side effects
than bupivacaine. The aim of this study was to compare the direct cardiac effects of the …

Methods We studied 20 patients scheduled for elective major abdominal surgery. After
induction of anaesthesia, all haemodynamic variables were recorded immediately before (T1) …

Introduction One of the main causes of death in European and US intensive care units is
sepsis. It involves a network of pro-inflammatory cytokines such as TNF-α, IL-1β and IL-6. …

Compared with bupivacaine, both agents may be considered as ‘more well tolerated’but not
as ‘totally well tolerated’, as they are still capable of inducing systemic and local toxicity. …

IMPLICATIONS: After continuous peripheral nerve blockades, the long-acting local anesthetics
bupivacaine and ropivacaine both induce fiber necrosis in porcine skeletal muscle tissue. …

Objective To assess the ability of the urinary biomarkers IGFBP7 (insulin-like growth factor-binding
protein 7) and TIMP-2 (tissue inhibitor of metalloproteinase 2) to early predict acute …