Analysis of Sciellin (SCEL) as a candidate gene in esophageal squamous cell carcinoma

…, N Saini, GD Trachiotis, LY Korman, B Liu… - Anticancer …, 2004 - ar.iiarjournals.org
Background: The aim of this study was to investigate whether a candidate gene, Sciellin (SCEL),
mapping to the chromosome 13q21-q31 is mutated in esophageal cancer. Materials …

An unbiased oncology compound screen to identify novel combination strategies

J O'Neil, Y Benita, I Feldman, M Chenard… - Molecular cancer …, 2016 - AACR
Combination drug therapy is a widely used paradigm for managing numerous human
malignancies. In cancer treatment, additive and/or synergistic drug combinations can convert …

Preclinical evaluation of the WEE1 inhibitor MK-1775 as single-agent anticancer therapy

…, B Long, HA Hirsch, I Feldman, Y Benita… - Molecular cancer …, 2013 - AACR
Inhibition of the DNA damage checkpoint kinase WEE1 potentiates genotoxic chemotherapies
by abrogating cell-cycle arrest and proper DNA repair. However, WEE1 is also essential …

[HTML][HTML] Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition

…, X Qu, NR Miselis, Y Liu, J Li, I Feldman, Y Benita… - Cancer cell …, 2012 - Springer
Background Inhibition of kinases involved in the DNA damage response sensitizes cells to
genotoxic agents by abrogating checkpoint-induced cell cycle arrest. CHK1 and WEE1 act in …

7046 Endoscopic mucosal resection using a cap method (emr-c) provides safe and effective treatment for early esophageal cancer.

…, NS Nishioka, B Bouma, M Farahvash, B Liu… - Gastrointestinal …, 2000 - Elsevier
Background: As part of an ongoing project between the National Cancer Institutes of the
United States and China, 2213 asymptomatic patients in Linzhou, China at high risk for …

Estrogen receptor regulation of carbonic anhydrase XII through a distal enhancer in breast cancer

…, T Howe Charn, A Waheed, WS Sly, CY Lin, ET Liu… - Cancer research, 2008 - AACR
The expression of carbonic anhydrase XII (CA12), a gene that encodes a zinc metalloenzyme
responsible for acidification of the microenvironment of cancer cells, is highly correlated …

What have we learned about socioeconomic inequalities in the spread of COVID-19? A systematic review

F Benita, L Rebollar-Ruelas… - Sustainable Cities and …, 2022 - Elsevier
This article aims to provide a better understanding of the associations between groups of
socioeconomic variables and confirmed cases of COVID-19. The focus is on cross-continental …

[HTML][HTML] Roles of Cullin-RING ubiquitin ligases in cardiovascular diseases

S Diaz, K Wang, B Sjögren, X Liu - Biomolecules, 2022 - mdpi.com
Maintenance of protein homeostasis is crucial for virtually every aspect of eukaryotic biology.
The ubiquitin-proteasome system (UPS) represents a highly regulated quality control …

Antibody conjugated PLGA nanoparticles for targeted delivery of paclitaxel palmitate: efficacy and biofate in a lung cancer mouse model

…, T Nassar, AN Ripin, O Schwob, J Borlak, S Benita - Small, 2013 - Wiley Online Library
Aberrant signaling of the epidermal growth factor receptor (EGFR) is common to a variety of
human cancers and is also found to be over‐expressed in most cases of non‐small cell lung …

An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia

Y Benita, H Kikuchi, AD Smith, MQ Zhang… - Nucleic acids …, 2009 - academic.oup.com
The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role in the transcriptional
response to oxygen flux. To gain insight into the molecular pathways regulated by HIF-…