The use of chemical compounds benefits society in a number of ways. Pesticides, for instance,
enable foodstuffs to be produced in sufficient quantities to satisfy the needs of millions of …

Cancer is the first cause of death in developed countries and the second in developing
countries. Concerning the most frequent worldwide-diagnosed cancer, primary liver cancer …

Oral gavage is a widely used method for administering substances to animals in
pharmacological and toxicological studies. The authors evaluated whether oral gavage causes …

Animal models, namely mice, have been used to study chemically induced carcinogenesis
due to their similarity to the histological and genetic features of human patients. …

The accumulation of heavy metals in the environment may have a wide range of health effects
on animals and humans. Thus, in this study, the concentrations of arsenic (As), cadmium (…

Several drugs have shown in vitro and in vivo pharmacological activity against urinary bladder
cancer. This review aims at compiling the different drugs evaluated in in vitro and in vivo …

To assess the efficacy of meloxicam, a non-steroidal anti-inflammatory drug (NSAID), on
three human urinary bladder-cancer cell lines (HT1376, T24 and 5637) and on mice urinary …

Hepatocellular carcinoma ( HCC ) is a common malignancy with poor clinical outcome, whose
histogenesis is the subject of intense debate. Specifically, expression of cytokeratins ( CK …

Objectives D/L-Nebivolol is a lypophilic β 1-adrenergic antagonist which is devoid of
intrinsic sympathomimetic activity and can increase nitric oxide (NO) bioavailability with its …

Background: A mouse model in which N-diethylnitrosamine (DEN) induces Hepatocellular
carcinoma (HCC) has histological and genetic resemblance to human tumours. Material and …