We have studied the interaction of 125I-antithrombin (125I-AT) with microvascular endothelial
cells (RFPEC) to localize the cellular site of anticoagulantly active heparan sulfate …

To define the factors responsible for the inactivation of the active fragment derived from
Factor XII (Factor XIIf ) in plasma, we studied the inactivation kinetics of Factor XIIf in various …

Endothelial cell production of anticoagulant heparan sulfate (HS act ) is controlled by the
Hs3st1 gene, which encodes the rate-limiting enzyme heparan sulfate 3-O-sulfotransferase-1 (3…

Background Externalization of phosphatidylserine (EPS) occurs in apoptotic-like spermatozoa
and could be used to remove them from sperm preparations to enhance sperm quality for …

Anticoagulant heparan sulfate proteoglycans bind and activate antithrombin by virtue of a
specific 3-O-sulfated pentasaccharide. They not only occur in the vascular wall but also in …

Understanding infertility and sterility requires knowledge of the molecular mechanisms
underlying sexual reproduction. We have found that male mice deficient for the gene encoding …

… de Agostini et al. revealed the relevance of this correlation by characterizing HS AT+ purified
from human follicular fluid (hFF) obtained from women undergoing oocyte pickup for in vitro …

Multisystem inflammatory syndrome in children (MIS-C) represents a rare but severe
complication of severe acute respiratory syndrome coronavirus 2 infection affecting children that …

Mucopolysaccharidosis IIIA is a hereditary disease caused by mutations in the sulfamidase
enzyme that participates in catabolism of heparan sulfate (HS), leading to HS fragment …

Heparan sulfate that contains antithrombin binding sites is designated as anticoagulant
heparan sulfate (HS act ) since, in vitro, it dramatically enhances the neutralization of …