[HTML][HTML] Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent

…, M Badiali, L Moi, G Bianco, A Cacchione… - Journal of translational …, 2014 - Springer
Background Ganglioglioma (GG) and pilocytic astrocytoma (PA) represent the most frequent
low-grade gliomas (LGG) occurring in paediatric age. LGGs not amenable of complete …

[HTML][HTML] Pediatric diffuse midline gliomas: An unfinished puzzle

…, G Del Baldo, F Fabozzi, M Vinci, A Cacchione… - Diagnostics, 2022 - mdpi.com
Diffuse midline glioma (DMG) is a heterogeneous group of aggressive pediatric brain tumors
with a fatal prognosis. The biological hallmark in the major part of the cases is H3K27 …

[HTML][HTML] DICER1 syndrome and cancer predisposition: from a rare pediatric tumor to lifetime risk

…, L Boccuto, I Alessi, G Del Baldo, A Cacchione… - Frontiers in …, 2021 - frontiersin.org
DICER1 syndrome is a rare genetic condition predisposing to hereditary cancer and caused
by variants in the DICER1 gene. The risk to present a neoplasm before the age of 10 years …

Robot-assisted stereotactic biopsy of diffuse intrinsic pontine glioma: a single-center experience

…, A De Benedictis, R Messina, A Cacchione… - World neurosurgery, 2017 - Elsevier
Background Diffuse intrinsic pontine glioma (DIPG) is a childhood tumor with a dismal prognosis.
Emerging molecular signatures have paved the way for stereotactic biopsy in selected …

[HTML][HTML] Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling

…, S Campello, E Papaleo, E Miele, A Cacchione… - Acta …, 2021 - Springer
Medulloblastoma (MB) is a childhood malignant brain tumour comprising four main subgroups
characterized by different genetic alterations and rate of mortality. Among MB subgroups, …

[HTML][HTML] BRAF V600E Inhibitor (Vemurafenib) for BRAF V600E Mutated Low Grade Gliomas

F Del Bufalo, G Ceglie, A Cacchione, I Alessi… - Frontiers in …, 2018 - frontiersin.org
Low-grade gliomas (LGG) are the most common central nervous system tumors in children.
Prognosis depends on complete surgical resection. For patients not amenable of gross total …

Growth hormone excess in children with neurofibromatosis type‐1 and optic glioma

…, F Del Bufalo, R Capolino, A Cacchione… - American Journal of …, 2017 - Wiley Online Library
In children with neurofibromatosis type 1 (NF1) and optic pathways glioma (OPG), growth
hormone (GH) excess has been rarely reported and mainly associated to central precocious …

[HTML][HTML] The peculiar challenge of bringing CAR-T cells into the brain: Perspectives in the clinical application to the treatment of pediatric central nervous system …

…, B De Angelis, P Merli, A Cacchione… - Frontiers in …, 2023 - frontiersin.org
Childhood malignant brain tumors remain a significant cause of death in the pediatric population,
despite the use of aggressive multimodal treatments. New therapeutic approaches are …

Targeted therapy for pediatric diffuse intrinsic pontine glioma: a single-center experience

…, A Carai, R Abbas, A Cacchione… - Therapeutic …, 2022 - journals.sagepub.com
Background: Diffuse intrinsic pontine glioma (DIPG) is a fatal disease with a median overall
survival (OS) of less than 12 months after diagnosis. Radiotherapy (RT) still remains the …

MRI features as a helpful tool to predict the molecular subgroups of medulloblastoma: state of the art

…, S Di Loreto, A Marrazzo, A Cacchione… - Therapeutic …, 2018 - journals.sagepub.com
Medulloblastoma is the most common malignant pediatric brain tumor. Medulloblastoma
should not be viewed as a single disease, but as a heterogeneous mixture of various …