Astrocytic brain tumours, including glioblastomas, are incurable neoplasms characterized
by diffusely infiltrative growth. Here we show that many tumour cells in astrocytomas extend …

The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase
(IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we …

Brain metastases from lung adenocarcinoma (BM-LUAD) frequently cause patient mortality.
To identify genomic alterations that promote brain metastases, we performed whole-exome …

Both the timing and molecular determinants of metastasis are unknown, hindering treatment
and prevention efforts. Here we characterize the evolutionary dynamics of this lethal …

The immune microenvironment of the brain differs from that of other organs and the role of
tumor-infiltrating lymphocytes (TILs) in brain metastases (BM), one of the most common and …

PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome
varies widely from benign to highly aggressive, ultimately fatal courses. Reliable …

Background Brain metastases are generally considered to be well demarcated from the
surrounding brain parenchyma, although infiltrative growth patterns have been observed. We …

Most high-grade meningiomas show a highly perturbed copy number profile and they are
enriched for TERT promoter mutations [6, 7, 11, 12]. In addition, homozygous focal deletions of …

… Author links open overlay panel Anna S. Berghoff 1 2 , Sophie Schur 1 2 , Lisa M.
Füreder 1 2 , Brigitte Gatterbauer 2 3 , Karin Dieckmann 2 4 , Georg Widhalm 2 3 , Johannes …

Antibody–drug conjugates (ADCs), a class of targeted cancer therapeutics combining monoclonal
antibodies with a cytotoxic payload via a chemical linker, have already been approved …