All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

The epidermal growth factor receptor (ErbB1 or EGFR) has been found to be altered in a
variety of human cancers. A number of agents targeting these receptors, including specific …

Purpose We previously identified in a single-center study a 76-gene prognostic signature
for lymph node-negative (LNN) breast cancer patients. The aim of this study was to validate …

Looked at from the genetic point-of-view cancer represents a daunting and, frankly, confusing
multiplicity of diseases (at least 100) that require an equally large variety of therapeutic …

Extracellular matrix (ECM) degradation is a critical process in tumor cell invasion and requires
membrane and released proteases focalized at membrane structures called invadopodia. …

The antineoplastic effect of paclitaxel is mainly related to its ability to bind the β subunit of
tubulin, thus preventing tubulin chain depolarization and inducing apoptosis. The relevance of …

Background The immunotherapy with immune checkpoints inhibitors (ICI) has changed the
life expectancy in metastatic melanoma (MM) patients. Nevertheless, several patients do not …

The term “biobanking” is often misapplied to any collection of human biological materials (biospecimens)
regardless of requirements related to ethical and legal issues or the …

Background Several studies looked for tumor biomarkers predictive for paclitaxel sensitivity
but till now no reliable biomarkers are available. The aim of this study was to verify the …

Western populations are becoming increasingly sedentary and the incidence of nonalcoholic
fatty liver disease (NAFLD) is increasing and becoming one of the most common causes of …