Dysregulation of IL-32 in myelodysplastic syndrome and chronic myelomonocytic leukemia modulates apoptosis and impairs NK function
AM Marcondes, AJ Mhyre… - Proceedings of the …, 2008 - National Acad Sciences
TNFα levels are elevated in the marrows of patients with myelodysplastic syndrome (MDS)
and are associated with high rates of apoptosis, which contributes to hematopoietic failure. …
and are associated with high rates of apoptosis, which contributes to hematopoietic failure. …
Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models
…, R Gottardo, MY Brusniak, AJ Mhyre… - Neuro …, 2021 - academic.oup.com
Background Diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs),
have a dismal prognosis, with less than 2% surviving 5 years postdiagnosis. The …
have a dismal prognosis, with less than 2% surviving 5 years postdiagnosis. The …
[HTML][HTML] Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
…, M Clarke, M Gewe, AJ Mhyre… - Nature …, 2017 - nature.com
Protein:protein interactions are among the most difficult to treat molecular mechanisms of
disease pathology. Cystine-dense peptides have the potential to disrupt such interactions, and …
disease pathology. Cystine-dense peptides have the potential to disrupt such interactions, and …
A potent peptide-steroid conjugate accumulates in cartilage and reverses arthritis without evidence of systemic corticosteroid exposure
…, DM Miller, C Mehlin, AD Strand, AJ Mhyre… - Science translational …, 2020 - science.org
On-target, off-tissue toxicity limits the systemic use of drugs that would otherwise reduce
symptoms or reverse the damage of arthritic diseases, leaving millions of patients in pain and …
symptoms or reverse the damage of arthritic diseases, leaving millions of patients in pain and …
[HTML][HTML] A TfR-binding cystine-dense peptide promotes blood–brain barrier penetration of bioactive molecules
…, AD Strand, KAK Finton, M Coxon, AJ Mhyre… - Journal of molecular …, 2020 - Elsevier
The impenetrability of the blood–brain barrier (BBB) to most conventional drugs impedes the
treatment of central nervous system (CNS) disorders. Interventions for diseases like brain …
treatment of central nervous system (CNS) disorders. Interventions for diseases like brain …
[HTML][HTML] Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function
…, MC DeFino, Y Namkung, JS Lyssand, AJ Mhyre… - Journal of Biological …, 2008 - ASBMB
The G-protein-coupled receptor (GPCR) GPR54 is essential for the development and
maintenance of reproductive function in mammals. A point mutation (L148S) in the second …
maintenance of reproductive function in mammals. A point mutation (L148S) in the second …
Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival
…, EJ Girard, YD Connor, F Zindy, AJ Mhyre… - Journal of Neuro …, 2021 - Springer
Purpose Tumor infiltration by immunosuppressive myeloid cells or tumor-associated
macrophages (TAMs) contributes to tumor progression and metastasis. In contrast to their adult …
macrophages (TAMs) contributes to tumor progression and metastasis. In contrast to their adult …
The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties
…, S Tom, M Luche, Y Khmelnitsky, AJ Mhyre… - Bioorganic & medicinal …, 2014 - Elsevier
The sodium glucose co-transporter 2 (SGLT2) has received considerable attention in recent
years as a target for the treatment of type 2 diabetes mellitus. This report describes the …
years as a target for the treatment of type 2 diabetes mellitus. This report describes the …
Tumour necrosis factor‐induced gene expression in human marrow stroma: clues to the pathophysiology of MDS?
DL Stirewalt, AJ Mhyre, M Marcondes… - British journal of …, 2008 - Wiley Online Library
Aberrant regulation of the tumour necrosis factor alpha gene (TNF) and stroma‐derived
signals are involved in the pathophysiology of myelodysplasia. Therefore, KG1a, a myeloid …
signals are involved in the pathophysiology of myelodysplasia. Therefore, KG1a, a myeloid …
Ex silico engineering of cystine-dense peptides yielding a potent bispecific T cell engager
…, A Bandaranayake, CE Correnti, AJ Mhyre… - Science translational …, 2022 - science.org
Cystine-dense peptides (CDPs) are a miniprotein class that can drug difficult targets with high
affinity and low immunogenicity. Tools for their design, however, are not as developed as …
affinity and low immunogenicity. Tools for their design, however, are not as developed as …