Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply
of allogeneic donor organs falls far short of the clinical need 1, 2, 3. Xenotransplantation of …

Background: Ischemic heart diseases are leading causes of death and reduced life quality
worldwide. Although revascularization strategies significantly reduce mortality after acute …

X-ray chest radiography is an inexpensive and broadly available tool for initial assessment
of the lung in clinical routine, but typically lacks diagnostic sensitivity for detection of …

Background Somatic cell nuclear transfer (SCNT) using genetically engineered donor cells
is currently the most widely used strategy to generate tailored pig models for biomedical …

Background The demand for donated human hearts far exceeds the number available.
Xenotransplantation of genetically modified porcine organs provides an alternative. In 2000, an …

Background Among other mismatches between human and pig, incompatibilities in the
blood coagulation systems hamper the xenotransplantation of vascularized organs. The …

The aim of this study was to assess the diagnostic value of x-ray dark-field radiography to
detect pneumothoraces in a pig model. Eight pigs were imaged with an experimental grating-…

Adeno‐associated viruses (AAVs) are frequently used for gene transfer and gene editing in
vivo, except for endothelial cells, which are remarkably resistant to unmodified AAV‐…

Malnutrition negatively impacts quality of life (QoL) in patients with head and neck cancer (HNC).
This is the first prospective study to assess the impact of malnutrition (defined by the …

Background In pig‐to‐human xenotransplantation, early cellular rejection reactions are
mediated by natural killer cells ( NK cells). Human NK cells are inhibited by HLA ‐E via CD 94/ …