Cancer cells become susceptible to natural killer cell killing after exposure to histone deacetylase inhibitors due to glycogen synthase kinase-3–dependent expression …

…, L Andresen, P Thor Straten, A Woetmann… - Cancer research, 2005 - AACR
We show that histone deacetylase (HDAC) inhibitors lead to functional expression of MHC
class I–related chain A and B (MICA/B) on cancer cells, making them potent targets for natural …

[HTML][HTML] The effect of short-chain fatty acids on human monocyte-derived dendritic cells

…, P Brigidi, N Ødum, T Litman, A Woetmann - Scientific reports, 2015 - nature.com
The gut microbiota is essential for human health and plays an important role in the
pathogenesis of several diseases. Short-chain fatty acids (SCFA), such as acetate, butyrate and …

Immature truncated O-glycophenotype of cancer directly induces oncogenic features

…, L Hansen, EP Bennett, A Woetmann… - Proceedings of the …, 2014 - National Acad Sciences
Aberrant expression of immature truncated O-glycans is a characteristic feature observed on
virtually all epithelial cancer cells, and a very high frequency is observed in early epithelial …

Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)

…, C Geisler, T Litman, A Woetmann… - Blood, The Journal …, 2011 - ashpublications.org
Cutaneous T-cell lymphomas (CTCLs) are the most frequent primary skin lymphomas.
Nevertheless, diagnosis of early disease has proven difficult because of a clinical and histologic …

[HTML][HTML] Constitutive STAT3 activation in intestinal T cells from patients with Crohn's disease

…, A Svejgaard, KW Eriksen, A Woetmann… - Journal of Biological …, 2003 - ASBMB
Via cytoplasmic signal transduction pathways, cytokines induce a variety of biological
responses and modulate the outcome of inflammatory diseases and malignancies. Crohn's …

STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes

Q Zhang, HY Wang, A Woetmann, PN Raghunath… - Blood, 2006 - ashpublications.org
In this study, we demonstrated that STAT3, a well-characterized transcription factor expressed
in continuously activated oncogenic form in the large spectrum of cancer types, induces in …

STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma

…, MA Wasik, E Ralfkiaer, N Ødum, A Woetmann - Cell cycle, 2013 - Taylor & Francis
The pathogenesis of cutaneous T-cell lymphoma (CTCL) remains elusive. Recent discoveries
indicate that the oncogenic microRNA miR-155 is overexpressed in affected skin from …

[HTML][HTML] Vitamin D-binding protein controls T cell responses to vitamin D

…, TB Levring, P Schjerling, A Woetmann… - BMC immunology, 2014 - Springer
Background In vitro studies have shown that the active form of vitamin D 3 , 1a,25-dihydroxyvitamin
D3 (1,25(OH) 2 D 3 ), can regulate differentiation of CD4 + T cells by inhibiting Th1 …

[HTML][HTML] Malignant inflammation in cutaneous T‐cell lymphoma—a hostile takeover

…, IV Litvinov, L Iversen, E Langhoff, A Woetmann… - Seminars in …, 2017 - Springer
Cutaneous T-cell lymphomas (CTCL) are characterized by the presence of chronically inflamed
skin lesions containing malignant T cells. Early disease presents as limited skin patches …

Characterizing the O-glycosylation landscape of human plasma, platelets, and endothelial cells

…, TD Madsen, MH Dziegiel, A Woetmann… - Blood …, 2017 - ashpublications.org
The hemostatic system comprises platelet aggregation, coagulation, and fibrinolysis, and is
critical to the maintenance of vascular integrity. Multiple studies indicate that glycans play …