Mechanisms underlying resistance to cetuximab in the HNSCC cell line: role of AKT inhibition in bypassing this resistance

M Rebucci, P Peixoto, A Dewitte… - International …, 2011 - spandidos-publications.com
EGFR is frequently overexpressed in head and neck squamous cell cancer (HNSCC).
Cetuximab is a monoclonal antibody designed to interact with EGFR, block its activation, reduce …

[HTML][HTML] New Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague

…, M Merchez, I Ricard, A Reboul, A Dewitte… - PLoS …, 2014 - journals.plos.org
Bubonic plague (a fatal, flea-transmitted disease) remains an international public health
concern. Although our understanding of the pathogenesis of bubonic plague has improved …

[HTML][HTML] A refined model of how Yersinia pestis produces a transmissible infection in its flea vector

A Dewitte, T Bouvenot, F Pierre, I Ricard… - PLoS …, 2020 - journals.plos.org
In flea-borne plague, blockage of the flea's foregut by Yersinia pestis hastens transmission
to the mammalian host. Based on microscopy observations, we first suggest that flea …

Nutrient depletion may trigger the Yersinia pestis OmpR‐EnvZ regulatory system to promote flea‐borne plague transmission

…, M Fernandez, A Dewitte… - Molecular …, 2019 - Wiley Online Library
The flea’s lumen gut is a poorly documented environment where the agent of flea‐borne
plague, Yersinia pestis, must replicate to produce a transmissible infection. Here, we report that …

[HTML][HTML] Polymorphism in the Yersinia LcrV antigen enables immune escape from the protection conferred by an LcrV-secreting Lactococcus lactis in a …

C Daniel, A Dewitte, M Marceau… - Frontiers in …, 2019 - frontiersin.org
Yersinioses caused by Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica
are significant concerns in human and veterinary health. The link between virulence …

Circulating thrombospondin 1 level as a surrogate marker in patients receiving cyclophosphamide-based metronomic chemotherapy

A Lansiaux, S Salingue, A Dewitte, S Clisant… - Investigational new …, 2012 - Springer
Several previous reports suggest that thrombospondin (TSP-1) may be a mediator of the
antiangiogenic effects of low-dose metronomic cyclophosphamide-based chemotherapy (MC). …

A Widefield Light Microscopy-Based Approach Provides Further Insights into the Colonization of the Flea Proventriculus by Yersinia pestis

A Dewitte, E Werkmeister, F Pierre… - Applied and …, 2023 - Am Soc Microbiol
Yersinia pestis (the agent of flea-borne plague) must obstruct the flea’s proventriculus to
maintain transmission to a mammalian host. To this end, Y. pestis must consolidate a mass that …

Interplay between Yersinia pestis and its flea vector in lipoate metabolism

T Bouvenot, A Dewitte, N Bennaceur, E Pradel… - The ISME …, 2021 - academic.oup.com
To thrive, vector-borne pathogens must survive in the vector’s gut. How these pathogens
successfully exploit this environment in time and space has not been extensively characterized. …

Evaluation of the Role of the opgGH Operon in Yersinia pseudotuberculosis and Its Deletion during the Emergence of Yersinia pestis

K Quintard, A Dewitte, A Reboul, E Madec… - Infection and …, 2015 - Am Soc Microbiol
The opgGH operon encodes glucosyltransferases that synthesize osmoregulated periplasmic
glucans (OPGs) from UDP-glucose, using acyl carrier protein (ACP) as a cofactor. OPGs …

Cilengitide targets pediatric glioma and neuroblastoma cells through cell detachment and anoikis induction

P Leblond, A Dewitte, F Le Tinier, C Bal-Mahieu… - Anti-cancer …, 2013 - journals.lww.com
The prognosis of children with high-grade glioma or high-risk neuroblastoma remains poor.
Cilengitide is a selective antagonist of αvβ3 and αvβ5 integrins, which are involved in tumor …