User profiles for ALEXANDRE ARCARO

Alexandre Arcaro

Inselspital, Bern University Hospital
Verified email at dkf.unibe.ch
Cited by 20392

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses

A Arcaro, MP Wymann - Biochemical Journal, 1993 - portlandpress.com
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of
neutrophils to the chemoattractant N-formylmethionyl-leucylphenylalanine (fMLP), and has …

The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications

A Arcaro, AS Guerreiro - Current genomics, 2007 - ingentaconnect.com
The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in human cancer and
represents an attractive target for therapies based on small molecule inhibitors. PI3K …

CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56lck Complexes

A Arcaro, C Grégoire, TR Bakker, L Baldi… - The Journal of …, 2001 - rupress.org
The extraordinary sensitivity of CD8 + T cells to recognize antigen impinges to a large extent
on the coreceptor CD8. While several studies have shown that the CD8β chain endows …

Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors

A Arcaro, MJ Zvelebil, C Wallasch… - … and cellular biology, 2000 - Taylor & Francis
The class II phosphoinositide 3-kinases (PI3K) PI3K-C2α and PI3K-C2β are two recently
identified members of the large PI3K family. Both enzymes are characterized by the presence of …

Essential role of CD8 palmitoylation in CD8 coreceptor function

A Arcaro, C Grégoire, N Boucheron, S Stotz… - The Journal of …, 2000 - journals.aai.org
To investigate the molecular basis that makes heterodimeric CD8αβ a more efficient coreceptor
than homodimeric CD8αα, we used various CD8 transfectants of T1. 4 T cell hybridomas, …

Immortalization of human alveolar epithelial cells to investigate nanoparticle uptake

…, J Gorelik, MJ Seckl, MJ O'Hare, A Arcaro… - American Journal of …, 2008 - atsjournals.org
Primary human alveolar type 2 (AT2) cells were immortalized by transduction with the
catalytic subunit of telomerase and simian virus 40 large-tumor antigen. Characterization by …

[HTML][HTML] Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity

A Arcaro, S Volinia, MJ Zvelebil, R Stein… - Journal of Biological …, 1998 - ASBMB
The cDNA for a human Class II phosphoinositide 3-kinase (PI 3-kinase C2β) with a C2
domain was cloned from a U937 monocyte cDNA library and the enzyme expressed in …

Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling

A Arcaro, M Aubert, MEE del Hierro, UK Khanzada… - Cellular signalling, 2007 - Elsevier
Lipid rafts are membrane microdomains distinct from caveolae, whose functions in polypeptide
growth factor signalling remain unclear. Here we show that in small cell lung cancer (…

[HTML][HTML] Targeting the insulin-like growth factor-1 receptor in human cancer

A Arcaro - Frontiers in pharmacology, 2013 - frontiersin.org
The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and
the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-…

[HTML][HTML] Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced …

OE Pardo, A Arcaro, G Salerno, S Raguz… - Journal of Biological …, 2002 - ASBMB
The involvement of fibroblast growth factor-2 (FGF-2) in the biology of small cell lung cancer
(SCLC) has not previously been investigated. Here we report that FGF-2 prevented …