User profiles for ALEXANDRE ARCARO
Alexandre ArcaroInselspital, Bern University Hospital Verified email at dkf.unibe.ch Cited by 20392 |
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3, 4, 5-trisphosphate in neutrophil responses
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of
neutrophils to the chemoattractant N-formylmethionyl-leucylphenylalanine (fMLP), and has …
neutrophils to the chemoattractant N-formylmethionyl-leucylphenylalanine (fMLP), and has …
The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications
A Arcaro, AS Guerreiro - Current genomics, 2007 - ingentaconnect.com
The phosphoinositide 3-kinase (PI3K) pathway is frequently activated in human cancer and
represents an attractive target for therapies based on small molecule inhibitors. PI3K …
represents an attractive target for therapies based on small molecule inhibitors. PI3K …
CD8β Endows CD8 with Efficient Coreceptor Function by Coupling T Cell Receptor/CD3 to Raft-associated CD8/p56lck Complexes
The extraordinary sensitivity of CD8 + T cells to recognize antigen impinges to a large extent
on the coreceptor CD8. While several studies have shown that the CD8β chain endows …
on the coreceptor CD8. While several studies have shown that the CD8β chain endows …
Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
A Arcaro, MJ Zvelebil, C Wallasch… - … and cellular biology, 2000 - Taylor & Francis
The class II phosphoinositide 3-kinases (PI3K) PI3K-C2α and PI3K-C2β are two recently
identified members of the large PI3K family. Both enzymes are characterized by the presence of …
identified members of the large PI3K family. Both enzymes are characterized by the presence of …
Essential role of CD8 palmitoylation in CD8 coreceptor function
A Arcaro, C Grégoire, N Boucheron, S Stotz… - The Journal of …, 2000 - journals.aai.org
To investigate the molecular basis that makes heterodimeric CD8αβ a more efficient coreceptor
than homodimeric CD8αα, we used various CD8 transfectants of T1. 4 T cell hybridomas, …
than homodimeric CD8αα, we used various CD8 transfectants of T1. 4 T cell hybridomas, …
Immortalization of human alveolar epithelial cells to investigate nanoparticle uptake
…, J Gorelik, MJ Seckl, MJ O'Hare, A Arcaro… - American Journal of …, 2008 - atsjournals.org
Primary human alveolar type 2 (AT2) cells were immortalized by transduction with the
catalytic subunit of telomerase and simian virus 40 large-tumor antigen. Characterization by …
catalytic subunit of telomerase and simian virus 40 large-tumor antigen. Characterization by …
[HTML][HTML] Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity
The cDNA for a human Class II phosphoinositide 3-kinase (PI 3-kinase C2β) with a C2
domain was cloned from a U937 monocyte cDNA library and the enzyme expressed in …
domain was cloned from a U937 monocyte cDNA library and the enzyme expressed in …
Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling
A Arcaro, M Aubert, MEE del Hierro, UK Khanzada… - Cellular signalling, 2007 - Elsevier
Lipid rafts are membrane microdomains distinct from caveolae, whose functions in polypeptide
growth factor signalling remain unclear. Here we show that in small cell lung cancer (…
growth factor signalling remain unclear. Here we show that in small cell lung cancer (…
[HTML][HTML] Targeting the insulin-like growth factor-1 receptor in human cancer
A Arcaro - Frontiers in pharmacology, 2013 - frontiersin.org
The insulin-like growth factor (IGF) signaling system plays a crucial role in human cancer and
the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-…
the IGF-1 receptor (IGF-1R) is an attractive drug target against which a variety of novel anti-…
[HTML][HTML] Fibroblast growth factor-2 induces translational regulation of Bcl-XL and Bcl-2 via a MEK-dependent pathway: correlation with resistance to etoposide-induced …
The involvement of fibroblast growth factor-2 (FGF-2) in the biology of small cell lung cancer
(SCLC) has not previously been investigated. Here we report that FGF-2 prevented …
(SCLC) has not previously been investigated. Here we report that FGF-2 prevented …