microRNAs (miRNAs) are a group of highly conserved small non-coding RNAs that were
found to enhance mRNA degradation or inhibit post-transcriptional translation. Accumulating …

Prohibitins (PHBs) are a highly conserved class of proteins first discovered as inhibitors of
cellular proliferation. Since then PHBs have been found to have a significant role in …

Energetically speaking, ribosome biogenesis is by far the most costly process of the cell and,
therefore, must be highly regulated in order to avoid unnecessary energy expenditure. Not …

Purpose: To analyze tear protein variations in patients suffering from dry eye symptoms in
the presence of tear film instability but without epithelial defects. Methods: Five microlitres of …

Purpose To evaluate the tear protein pattern in patients with recent subjective symptoms of
dry eye (DE) and with poor distinctive DE clinical signs. Methods One hundred sixty patients …

Akt/PKB is a central activator of multiple signaling pathways coupled with a large number of
stimuli. Although both localization and activity of Akt in the nuclear compartment are well-…

Aging results in a progressive decline in skeletal muscle mass, strength and function, a
condition known as sarcopenia. This pathological condition is due to multifactorial processes …

Phospholipase C β 1 (PLCβ 1 ) signaling in both cell proliferation and differentiation has
been largely investigated, but its role in myoblast differentiation is still unclear. The C2C12 …

Background Beyond its possible correlation with stemness of tumor cells, CD133/prominin1
is considered an important marker in breast cancer, since it correlates with tumor size, …

A number of cancers possess constitutive activity of the dsRNA-dependent kinase, PKR.
Inhibition of PKR in these cancers leads to tumor cell death. We recently reported the increased …