Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by
the pepper extract capsaicin and is expressed in sensory nerves that innervate the airway …

Postmortem studies have shown that airway wall thickening is present in asthmatic patients
and may play a pathophysiologic role. We investigated the presence and characteristics of …

Bronchial asthma is a common inflammatory disease caused by the interaction of genetic
and environmental factors 1 , 2 . Through a genome-wide association study and a replication …

Airway wall thickening has been assumed to cause airway hyperresponsiveness, but a
protective effect against airway narrowing has also been suggested. We investigated the …

Background Emphysematous change as assessed by CT imaging has been reported to
correlate with COPD prognostic factors such as FEV 1 and diffusing capacity of the lung for …

Background Periostin, an extracellular matrix protein, contributes to subepithelial thickening
in asthmatic airways, and its serum levels reflect airway eosinophilic inflammation. However, …

Asthma and COPD are the most prevalent of lung diseases and contribute an enormous
burden of morbidity in North America and globally. In both conditions, inflammation leads to …

We have investigated the efficacy of a clarithromycin-containing four-drug regimen for
Mycobacterium avium complex (MAC) pulmonary disease in 46 patients without acquired …

Background: The association between gastro-oesophageal reflux disease (GORD) and
chronic obstructive pulmonary disease (COPD) exacerbation has so far remained unclear. …

Subepithelial-layer thickening, a pathological feature of airway remodelling, is present in
cough-variant asthma. In bronchial biopsy samples we found mean subepithelial-layer …