Lipoteichoic Acids from Lactobacillus Strains Elicit Strong Tumor Necrosis Factor Alpha-Inducing Activities in Macrophages through Toll-Like Receptor 2

T Matsuguchi, A Takagi, T Matsuzaki… - Clinical and Vaccine …, 2003 - Am Soc Microbiol
Lactobacilli are nonpathogenic gram-positive inhabitants of microflora. At least some Lactobacillus
strains have been postulated to have health beneficial effects, such as the stimulation …

Enhancement of natural killer cytotoxicity delayed murine carcinogenesis by a probiotic microorganism

A Takagi, T Matsuzaki, M Sato, K Nomoto… - …, 2001 - academic.oup.com
Regulation of innate immunity may be an effective means of cancer control. Delaying cancer
onset is regarded as an important mode of action in cancer prevention. We have been …

Three-dimensional cellular spheroid formation provides human prostate tumor cells with tissue-like features

A Takagi, M Watanabe, Y Ishii, J Morita… - Anticancer …, 2007 - ar.iiarjournals.org
Background: Alterations in the cellular biological responses were examined in a series of
LNCaP human prostate tumor cells growing under different conditions. Materials and Methods: …

[HTML][HTML] Possibility of breast cancer prevention: use of soy isoflavones and fermented soy beverage produced using probiotics

A Takagi, M Kano, C Kaga - International journal of molecular sciences, 2015 - mdpi.com
The various beneficial effects of soybeans, which are rich in phytochemicals, have received
much attention because of increasing health awareness. Soy milk that has been fermented …

[HTML][HTML] Intestinal Microflora: Probiotics and Autoimmunity1

T Matsuzaki, A Takagi, H Ikemura, T Matsuguchi… - The Journal of …, 2007 - Elsevier
Lactobacillus casei strain Shirota (LcS) has been demonstrated to have beneficial effects in
numerous murine disease models via host immune modulation. It has also been reported …

Altered methylation of multiple genes in carcinogenesis of the prostate

…, M Watanabe, Y Yamada, A Takagi… - … journal of cancer, 2003 - Wiley Online Library
The methylation status of 7 genes was examined in four cell lines, 36 samples of benign
prostatic hyperplasia (BPH), 20 samples of prostatic intraepithelial neoplasia (PIN) and 109 …

Oxaliplatin, a potent inhibitor of survivin, enhances paclitaxel-induced apoptosis and mitotic catastrophe in colon cancer cells

…, H Yamamoto, CY Ngan, A Takagi… - Japanese journal of …, 2005 - academic.oup.com
Background: Clinical studies have demonstrated that oxaliplatin, a novel platinum derivative,
is a potent chemotherapeutic agent, especially when combined with other reagents. The …

Relationship between the in vitro response of dendritic cells to Lactobacillus and prevention of tumorigenesis in the mouse

A Takagi, H Ikemura, T Matsuzaki, M Sato… - Journal of …, 2008 - Springer
Background Some strains of lactobacilli stimulate immune cells, yet little is known about their
potency in cancer prevention. We have previously reported that Lactobacillus casei Shirota …

Oxaliplatin induces mitotic catastrophe and apoptosis in esophageal cancer cells

CY Ngan, H Yamamoto, A Takagi, Y Fujie… - Cancer …, 2008 - Wiley Online Library
The platinum‐based chemotherapeutic agent oxaliplatin displays a wide range of antitumor
activities. However, the underlying molecular responses to oxaliplatin in esophageal cancer …

Lactobacillus casei Shirota enhances the preventive efficacy of soymilk in chemically induced breast cancer

C Kaga, A Takagi, M Kano, S Kado, I Kato… - Cancer …, 2013 - Wiley Online Library
Soy foods are known to be effective for breast cancer prevention. The habitual consumption
of soy isoflavones in combination with the probiotic L actobacillus casei S hirota ( LcS ) was …