[HTML][HTML] A novel subtype of type 1 diabetes mellitus characterized by a rapid onset and an absence of diabetes-related antibodies

A Imagawa, T Hanafusa, J Miyagawa… - New England journal …, 2000 - Mass Medical Soc
Background and Methods Type 1 diabetes mellitus is now classified as autoimmune (type
1A) or idiopathic (type 1B), but little is known about the latter. We classified 56 consecutive …

Fulminant type 1 diabetes: a nationwide survey in Japan

A Imagawa, T Hanafusa, Y Uchigata… - Diabetes …, 2003 - Am Diabetes Assoc
OBJECTIVE— To describe the clinical and immunologic characteristics of fulminant type 1
diabetes, a novel subtype of type 1 diabetes, we conducted a nationwide survey. RESEARCH …

Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens …

…, K Yamamoto, M Waguri, A Imagawa… - The Journal of …, 1993 - Am Soc Clin Investig
We examined pancreas biopsy specimens from 18 newly diagnosed insulin-dependent
diabetes mellitus (IDDM) patients to elucidate the mechanism underlying beta cell destruction. …

Fulminant type 1 diabetes: a novel clinical entity requiring special attention by all medical practitioners

T Hanafusa, A Imagawa - Nature clinical practice Endocrinology & …, 2007 - nature.com
Fulminant type 1 diabetes is a recently discovered subtype of type 1 diabetes. It is defined
as diabetes in which the process of β-cell destruction and the progression of hyperglycemia …

Report of the Committee of the Japan Diabetes Society on the research of fulminant and acute-onset type 1 diabetes mellitus: new diagnostic criteria of fulminant type …

A Imagawa, T Hanafusa, T Awata, H Ikegami… - Diabetology …, 2012 - Springer
We have revised a part of the diagnostic criteria for fulminant type 1 diabetes. The new criteria
were set both to express the essence of this disease of rapid increase of patients’ blood …

Elevated serum concentration of adipose-derived factor, adiponectin, in patients with type 1 diabetes

A Imagawa, T Funahashi, T Nakamura… - Diabetes …, 2002 - search.proquest.com
Adiponectin, also referred to as Acrp30, AdipoQ, and GBP28, is a plasma protein exclusively
produced by adipose tissue and a possible insulin-sensitizing agent (1-6). Serum …

[HTML][HTML] Cellular hypoxia of pancreatic β-cells due to high levels of oxygen consumption for insulin secretion in vitro

…, H Okuyama, T Takeda, H Iwahashi, A Imagawa… - Journal of Biological …, 2011 - ASBMB
Cellular oxygen consumption is a determinant of intracellular oxygen levels. Because of the
high demand of mitochondrial respiration during insulin secretion, pancreatic β-cells …

Overexpression of dominant-negative mutant hepatocyte nuclear factor-1α in pancreatic β-cells causes abnormal islet architecture with decreased expression of E …

…, K Okita, H Iwahashi, Q Zhu, Y Cao, A Imagawa… - Diabetes, 2002 - Am Diabetes Assoc
One subtype of maturity-onset diabetes of the young (MODY)-3 results from mutations in the
gene encoding hepatocyte nuclear factor (HNF)-1α. We generated transgenic mice …

Pancreatic biopsy as a procedure for detecting in situ autoimmune phenomena in type 1 diabetes: close correlation between serological markers and histological …

A Imagawa, T Hanafusa, S Tamura, M Moriwaki… - Diabetes, 2001 - Am Diabetes Assoc
To better understand the pathogenesis of type 1 diabetes, we have developed pancreatic
biopsy under laparoscope for recent-onset type 1 diabetic patients. The patients included 29 …

Requirement of Fas for the development of autoimmune diabetes in nonobese diabetic mice

N Itoh, A Imagawa, T Hanafusa, M Waguri… - The Journal of …, 1997 - rupress.org
Insulin-dependent diabetes mellitus (IDDM) is assumed to be a T cell–mediated autoimmune
disease. To investigate the role of Fas-mediated cytotoxicity in pancreatic β cell destruction…