In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

Curative cancer therapy remains a major challenge particularly in cancers displaying multidrug
resistance (MDR). The MDR phenotype is characterized by cross-resistance to a wide …

Recent genomewide analyses of alternative splicing (AS) indicate that up to 70% of human
genes may have alternative splice forms, suggesting that AS together with various …

In solid tumors, the presence of lymph node–like structures called tertiary lymphoid structures
(TLS) is associated with improved patient survival. However, little is known about how TLS …

Background Circulating cell-free miRNAs have emerged as promising minimally-invasive
biomarkers for early detection, prognosis and monitoring of cancer. They can exist in the …

The aim of this study was to identify microRNAs in urinary exosomes that are differently
expressed in prostate cancer patients and healthy donors. For this purpose, RNA was extracted …

Cancer-derived extracellular vesicles (EVs) have been detected in the bloodstream and other
biofluids of cancer patients. They carry various tumor-derived molecules such as mutated …

Prostate cancer, the second most frequently diagnosed cancer in males worldwide, is
estimated to be diagnosed in 1.1 million men per year. Introduction of PSA testing substantially …

Autoantibodies against tumor‐associated antigens are very attractive biomarkers for the
development of noninvasive serological tests for the early detection of cancer because of their …

An important role for tumor infiltrating B lymphocytes (TIL-B) in the immune response to
cancer is emerging; however, very little is known about the antigen specificity of antibodies …