[HTML][HTML] Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P …

…, P Ren, J Sauser, A Ruzin, DE Tabor, A Akhgar… - Critical Care, 2022 - Springer
Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in
hospitalised patients is associated with high mortality. The effectiveness of the bivalent, …

[HTML][HTML] Collagen type III and VI remodeling biomarkers are associated with kidney fibrosis in lupus nephritis

F Genovese, A Akhgar, SS Lim, AB Farris, M Battle… - Kidney360, 2021 - journals.lww.com
Background Lupus nephritis (LN) occurs in< 40% of patients with SLE. Reliable biomarkers
of kidney damage are needed to identify patients with SLE at risk of developing LN to …

Prevalence of IgG and neutralizing antibodies against Staphylococcus aureus alpha-toxin in healthy human subjects and diverse patient populations

Y Wu, X Liu, A Akhgar, JJ Li, H Mok… - Infection and …, 2018 - Am Soc Microbiol
Staphylococcus aureus causes an array of serious infections resulting in high morbidity and
mortality worldwide. This study evaluated naturally occurring serum anti-alpha-toxin (anti-AT…

Urinary markers differentially associate with kidney inflammatory activity and chronicity measures in patients with lupus nephritis

A Akhgar, D Sinibaldi, L Zeng, AB Farris… - Lupus Science & …, 2023 - lupus.bmj.com
Objective Lupus nephritis (LN) is diagnosed by biopsy, but longitudinal monitoring assessment
methods are needed. Here, in this preliminary and hypothesis-generating study, we …

Pharmacological profile of MEDI-551, a novel anti-CD19 antibody, in human CD19 transgenic mice

S Gallagher, S Turman, I Yusuf, A Akhgar, Y Wu… - International …, 2016 - Elsevier
B cell depletion therapy is beneficial for patients with B cell malignancies and autoimmune
diseases. CD19, a transmembrane protein, is expressed on a vast majority of normal and …

[HTML][HTML] Selection of a ligand-binding neutralizing antibody assay for benralizumab: comparison with an antibody-dependent cell-mediated cytotoxicity (ADCC) cell …

Y Wu, A Akhgar, JJ Li, B Yu, C Chen, N Lee, WI White… - The AAPS Journal, 2018 - Springer
Assessment of anti-drug antibodies (ADAs) for neutralizing activity is important for the clinical
development of biopharmaceuticals. Two types of neutralizing antibody (NAb) assays (…

[HTML][HTML] A neutralizing antibody assay based on a reporter of antibody-dependent cell-mediated cytotoxicity

Y Wu, JJ Li, HJ Kim, X Liu, W Liu, A Akhgar… - The AAPS journal, 2015 - Springer
Benralizumab is a humanized anti-IL5 receptor α (IL5Rα) monoclonal antibody (mAb) with
enhanced (afucosylation) antibody-dependent cell-mediated cytotoxicity (ADCC) function. An …

Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans

…, J Kwagyan, R Poirier, S Akter, A Akhgar… - Anticancer …, 2008 - ar.iiarjournals.org
Background: Recent evidence indicates that single nucleotide polymorphisms (SNPs) in the
Cox-2 gene may modulate the risk of colorectal adenoma development. Patients and …

Expected Outcomes from Family Medicine Specialized Graduates in Iranian Health System from the Viewpoints of Stakeholders: A Qualitative Study

AN Akhgar, M Alizadeh, R Khodayari-Zarnaq… - Depiction of …, 2020 - doh.tbzmed.ac.ir
Background and Objectives: The purpose of training and applying family physicians in the
health system is to optimize rating the services and referral system. The purpose of this study …

[HTML][HTML] Prevalence of tuberculosis among mentally ill patients in conflict-stricken Afghanistan: A cross-sectional study

…, KM Rashidi, A Hamim, MH Akhgar, B Ahmad… - International Journal of …, 2019 - Elsevier
Objectives Tuberculosis (TB) and mental illness share underlying factors such as poverty,
malnutrition, and stress. This study’s objective was to determine the prevalence of TB among …