Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology

AL VanWert, MR Gionfriddo… - Biopharmaceutics & drug …, 2010 - Wiley Online Library
Our understanding of the mechanisms behind inter‐ and intra‐patient variability in drug
response is inadequate. Advances in the cytochrome P450 drug metabolizing enzyme field have …

Organic anion transporter 3 (oat3/slc22a8) interacts with carboxyfluoroquinolones, and deletion increases systemic exposure to ciprofloxacin

AL VanWert, C Srimaroeng, DH Sweet - Molecular pharmacology, 2008 - ASPET
Carboxyfluoroquinolones, such as ciprofloxacin, are used for the treatment of numerous
infectious diseases. Renal secretion is a major determinant of their systemic and urinary …

Medicinal properties of alpha-santalol, a naturally occurring constituent of sandalwood oil

…, S Hughes, E Mabry, A Knopp, AL VanWert… - Natural product …, 2019 - Taylor & Francis
Alpha-santalol is a naturally occurring sesquiterpene that is derived from sandalwood oil. Its
wide range of health benefits have been attributed to the modulation of various signalling …

Organic anion transporter 3 (Oat3/Slc22a8) knockout mice exhibit altered clearance and distribution of penicillin G

AL VanWert, RM Bailey… - American Journal of …, 2007 - journals.physiology.org
The interaction of renal basolateral organic anion transporter 3 (Oat3) with commonly used
pharmacotherapeutics (eg, NSAIDs, β-lactams, and methotrexate) has been studied …

α-Santalol, a derivative of sandalwood oil, induces apoptosis in human prostate cancer cells by causing caspase-3 activation

A Bommareddy, B Rule, AL VanWert, S Santha… - Phytomedicine, 2012 - Elsevier
The anticancer effects of α-santalol, a major component of sandalwood oil, have been reported
against the development of certain cancers such as skin cancer both in vitro and in vivo. …

Impaired Clearance of Methotrexate in Organic Anion Transporter 3 (Slc22a8) Knockout Mice: A Gender Specific Impact of Reduced Folates

AL VanWert, DH Sweet - Pharmaceutical research, 2008 - Springer
Purpose To elucidate the role of the renal basolateral transporter, Oat3, in the disposition of
methotrexate. Materials and Methods Chinese hamster ovary cells expressing mouse Oat3 …

Chemoprevention of prostate cancer by major dietary phytochemicals

…, A Antal, Z Witczak, DF Mccune, AL Vanwert - Anticancer …, 2013 - ar.iiarjournals.org
Prostate cancer continues to be one of the most commonly diagnosed diseases and the second
leading cause of cancer-related deaths among men in the United States. Options exist to …

Organic anion transporter 3 interacts selectively with lipophilic β-lactam antibiotics

…, S Witkowski, A Bommareddy, AL VanWert - Drug Metabolism and …, 2013 - ASPET
Transporters are major determinants of the disposition of xenobiotics and endogenous
chemicals in the body. Organic anion transporter 3 (Oat3) functions in the kidney and brain to …

Additive toxic effect of deltamethrin and cadmium on hepatic, hematological, and immunological parameters in mice

…, AT Aziz, S Saggu, AL VanWert… - Toxicology and …, 2017 - journals.sagepub.com
Exposure to natural and man-made environmental toxins concurrently can pose a greater
threat to multiple organs. In the present work, we investigated interactions between …

[HTML][HTML] Analytical methods for oxalate quantification: the ubiquitous organic anion

B Misiewicz, D Mencer, W Terzaghi, AL VanWert - Molecules, 2023 - mdpi.com
Oxalate is a divalent organic anion that affects many biological and commercial processes.
It is derived from plant sources, such as spinach, rhubarb, tea, cacao, nuts, and beans, and …