Extracellular matrix structure
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and …
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and …
Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting
Matrix metalloproteinases (MMPs) consist of a multigene family of zinc‐dependent extracellular
matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as …
matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as …
A guide to the composition and functions of the extracellular matrix
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …
provides structural support for the cells and tissues. Accumulated knowledge clearly …
Glycosaminoglycans: key players in cancer cell biology and treatment
Glycosaminoglycans are natural heteropolysaccharides that are present in every mammalian
tissue. They are composed of repeating disaccharide units that consist of either sulfated or …
tissue. They are composed of repeating disaccharide units that consist of either sulfated or …
The extracellular matrix as a multitasking player in disease
Extracellular matrices ( ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …
Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting
The expression of proteoglycans (PGs), essential macromolecules of the tumor microenvironment,
is markedly altered during malignant transformation and tumor progression. Synthesis …
is markedly altered during malignant transformation and tumor progression. Synthesis …
Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs)…
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs)…
Syndecans–key regulators of cell signaling and biological functions
…, D Nikitovic, HAB Multhaupt, AD Theocharis… - The FEBS …, 2017 - Wiley Online Library
Syndecans are a small family of four transmembrane proteoglycans in mammals. They have
similar structural organization, consisting of an N‐terminal ectodomain, single …
similar structural organization, consisting of an N‐terminal ectodomain, single …
[HTML][HTML] Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of …
In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly as …
molecules that regulate several cell functions either by the genomic pathway acting directly as …
Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases
… Proteoglycans also exert major roles as key molecular determinants throughout tumorigenesis
and angiogenesis as comprehensively reviewed by Theocharis and Karamanos in this …
and angiogenesis as comprehensively reviewed by Theocharis and Karamanos in this …