Extracellular matrix structure

AD Theocharis, SS Skandalis, C Gialeli… - Advanced drug delivery …, 2016 - Elsevier
Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins, and …

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

C Gialeli, AD Theocharis, NK Karamanos - The FEBS journal, 2011 - Wiley Online Library
Matrix metalloproteinases (MMPs) consist of a multigene family of zinc‐dependent extracellular
matrix (ECM) remodeling endopeptidases implicated in pathological processes, such as …

A guide to the composition and functions of the extracellular matrix

NK Karamanos, AD Theocharis, Z Piperigkou… - The FEBS …, 2021 - Wiley Online Library
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Glycosaminoglycans: key players in cancer cell biology and treatment

…, T Tsegenidis, E Karousou, AD Theocharis… - The FEBS …, 2012 - Wiley Online Library
Glycosaminoglycans are natural heteropolysaccharides that are present in every mammalian
tissue. They are composed of repeating disaccharide units that consist of either sulfated or …

The extracellular matrix as a multitasking player in disease

AD Theocharis, D Manou, NK Karamanos - The FEBS journal, 2019 - Wiley Online Library
Extracellular matrices ( ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting

AD Theocharis, SS Skandalis, GN Tzanakakis… - The FEBS …, 2010 - Wiley Online Library
The expression of proteoglycans (PGs), essential macromolecules of the tumor microenvironment,
is markedly altered during malignant transformation and tumor progression. Synthesis …

Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics

NK Karamanos, Z Piperigkou, AD Theocharis… - Chemical …, 2018 - ACS Publications
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans (PGs/GAGs)…

Syndecans–key regulators of cell signaling and biological functions

…, D Nikitovic, HAB Multhaupt, AD Theocharis… - The FEBS …, 2017 - Wiley Online Library
Syndecans are a small family of four transmembrane proteoglycans in mammals. They have
similar structural organization, consisting of an N‐terminal ectodomain, single …

[HTML][HTML] Cross-talk between estradiol receptor and EGFR/IGF-IR signaling pathways in estrogen-responsive breast cancers: focus on the role and impact of …

…, N Afratis, G Smirlaki, D Nikitovic, AD Theocharis… - Matrix Biology, 2014 - Elsevier
In hormone-dependent breast cancer, estrogen receptors are the principal signaling
molecules that regulate several cell functions either by the genomic pathway acting directly as …

Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases

NK Karamanos, AD Theocharis, T Neill, RV Iozzo - Matrix Biology, 2019 - Elsevier
… Proteoglycans also exert major roles as key molecular determinants throughout tumorigenesis
and angiogenesis as comprehensively reviewed by Theocharis and Karamanos in this …