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30952716,25077897,28822888,30098066,23916913,27450722,32561477,28416737,22844075,26517520,27362807,27384992,27612490,22806877,20530710,24065731,28515374,21767894,25590805,25384171,25607753,26723875,32896579,30676858,24919575,33314735,23533265,22821179,19952121,24939055,30213498,31791326,31331328,32552611,22891040,27264264,32464330,29927769,29717264,26962872,23863134,24165158,28230005,26926157,31043587,30453282,22592212,33287873,26528827,29960010,24893891,31324888,23012248,18199556,29449529,26282169,23382048,26554308,32521387,25831463,33391507,34855271,22993320,25730907,32433828,26789630,21712475,27431492,19188161,24331411,21775534,26682870,20225761,32404161,24750242,16024644,26418897,26508839,23515752,27251290,30952931,26370161,28167505,27419630,31931029,28866043,32446385,26310719,31216465,26124204,30194074,24223799,25368326,29374157,19459856,29526178,28829429,31092564,26334838,31417255,19509246,27821131,27827863,30365122,27852038,26583948,28287083,28289161,20647329,30759826,28749535,24789511,24471765,24953979,26845230,26187428,32483443,24386407,23588221,26090892,20619923,23359111,25404267,26500058,25117641,30302022,33894221,34635651,32163227,27145431,32081857,29555874,29858032,31823748,32888648,31747941,24698130,31446643,32561533,29118262,29902012,30911072,22144665,26744526,30109782,22209766,31874554,23686707,24052078,32368855,31470227,20459769,31432603,33262410,31323891,27616574,23874880,32694521,26375053,29449326,34572484,29229632,31857719,34210314,20878103,18632637,33297461,25271963,27196768,30796032,30382076,31000705,31132309,31228625,24033722,30309221,23229345,31185393,35408753,31689114,32599977,30832751,30429039,29524558,22552292,20124471,31368815,32747363,22319204,29202823,27573423,29337056,34830169,31359792,36595561,22174910,29717218,29462256,22227828,23553849,30537515,31410582,24952482,19491268,22715590,31560541,22738915,24166505,23769347,18408761,23418523,31273063,31660987,29934325,22873759,11857424,30950666,29972257,29789542,31416192,24121490,33544933,23720767,24682747,30030903,33471376,33812963,21594003,21443472,26036303,31118055,32979839,33775711,24758913,34558640,33656275,30521971,28566436,25780909,25511613,31131689,29530932,31010733,35840561,32497570,30868964,25521095,19351834,32366411,23514946,18493719,20530582,35481881,24595136,20129249,30097569,36529523,33994852,25511614,29618618,17913857,29239135,30467317,25034590,23345546,28669334,31316001,25138052,32414908,31739412,36804545,25189483,28684780,24248265,31399492,25119973,28522592,30801702,17876048,32082304,34148892,28583846,30827323,30830869,31454652,28103975,32878980,24830724,32194831,29532998,33037411,23733853,26162689,30087143,25185500,23493311,25343452,36151006,33042262,25210794,23152004,24108744,23990708,28159915,19353773,30243717,23401451,36787696,19243280,37042119,32816907,18520302,31534543,24752335,27379696,26358373,29548337,29215723,30471829,30381967,24463348,29594878,30548188,20489150,33243531,31718182,17082181,25871388,31401315,36902446,34751282,34990648,30307719,25975640,21208802,23749888,32683166,32066763,32768937,25382203,36080307,21208906,18483355,32093124,34607394,18322248,30663564,34445110,36625328,23303741,35313239,20628392,18296914,32429639,36066413,34944063,30419315,29277186,29263244,20940293,31037333,33450055,34987637,30201763,36048538,33355298,21062927,21551260,22183882,33667849,24307395,20663904,34247147,33033232,18593895,27893711,33166766,30154228,31446247,34319535,33335306,22181674,18687633,31116490,34516823,28445002,34035882,20718710,30678647,31125641,29945960,30527314,32023774,15638955,34742684,32572029,29899551,28433633,30268747,29125233,32058238,27786612,24946002,23900136,30742982,27770511,16538075,34491761,35301141,17510392,34302809,30528977,30362533,36282234,30899640,21533169,28081601,30054711,29651165,32005679,30471423,24709418,22952420,30171047,28003335,23593472,30268457,27880046,36760347,31889035,25263444,19625781,36153311,35427766,32094923,33794753,34686341,23698466,18852144,36129611,29613856,24138718,32276600,36450508,30478424,21262974,31121829,33934008,34656057,33331136,23307186,30504063,26745059,30593826,22245727,35022206,24931608,30578392,24034250,35939534,27160532,33435251,26560147,35880513,23897823,34112110,31600169,26980196,32471561,32124699,34662547,26627081,31544704,31892559,31880357,31639425,16969107,36533580,25416789,30224681,36000948,35315726,32115500,22804236,12415691,24092472,36394145,31573595,33912379,33500390,32125853,33409897,26010604,23614618,29945964,26271675,30523199,26768339,1315778,28878208,31895569,31555510,30067876,18303428,34425993,25229646,30811850,36740689,30962319,30153566,31801945,29622797,33788714,29522162,29561705,30796972,20364069,28739874,32144093,31083461,36990572,33644823,31898183,20388509,34290605,30811294,35081479,30342190,31291585,29976202,33164261,28300840,8134396,10209964,29853657,30724109,17264670,35351890,19887599,29298657,33543615,29384086,37122754,33183223,35841121,23400472,30242093,22306870,22935054,32243152,30292401,30448009,19451690,24661111,23951344,3248915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Ganetespib in Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer.

Kurihara E, Shien K, Torigoe H, Takeda T, Takahashi Y, Ogoshi Y, Yoshioka T, Namba K, Sato H, Suzawa K, Yamamoto H, Soh J, Okazaki M, Shien T, Tomida S, Toyooka S. Kurihara E, et al. Anticancer Res. 2019 Apr;39(4):1767-1775. doi: 10.21873/anticanres.13283. Anticancer Res. 2019. PMID: 30952716

The HSP90 inhibitor ganetespib potentiates the antitumor activity of EGFR tyrosine kinase inhibition in mutant and wild-type non-small cell lung cancer.

Smith DL, Acquaviva J, Sequeira M, Jimenez JP, Zhang C, Sang J, Bates RC, Proia DA. Smith DL, et al. Target Oncol. 2015 Jun;10(2):235-45. doi: 10.1007/s11523-014-0329-6. Epub 2014 Aug 1. Target Oncol. 2015. PMID: 25077897 Free PMC article.

Apatinib enhances antitumour activity of EGFR-TKIs in non-small cell lung cancer with EGFR-TKI resistance.

Li F, Zhu T, Cao B, Wang J, Liang L. Li F, et al. Eur J Cancer. 2017 Oct;84:184-192. doi: 10.1016/j.ejca.2017.07.037. Epub 2017 Aug 17. Eur J Cancer. 2017. PMID: 28822888

Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer.

Sato H, Yamamoto H, Sakaguchi M, Shien K, Tomida S, Shien T, Ikeda H, Hatono M, Torigoe H, Namba K, Yoshioka T, Kurihara E, Ogoshi Y, Takahashi Y, Soh J, Toyooka S. Sato H, et al. Cancer Sci. 2018 Oct;109(10):3183-3196. doi: 10.1111/cas.13763. Epub 2018 Sep 14. Cancer Sci. 2018. PMID: 30098066 Free PMC article.

Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo.

Xie M, He CS, Wei SH, Zhang L. Xie M, et al. Eur J Cancer. 2013 Nov;49(16):3559-72. doi: 10.1016/j.ejca.2013.07.007. Epub 2013 Aug 2. Eur J Cancer. 2013. PMID: 23916913

Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment.

Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY. Shi P, et al. Cancer Lett. 2016 Oct 1;380(2):494-504. doi: 10.1016/j.canlet.2016.07.021. Epub 2016 Jul 19. Cancer Lett. 2016. PMID: 27450722

Lymecycline reverses acquired EGFR-TKI resistance in non-small-cell lung cancer by targeting GRB2.

Chen Y, Wu J, Yan H, Cheng Y, Wang Y, Yang Y, Deng M, Che X, Hou K, Qu X, Zou D, Liu Y, Zhang Y, Hu X. Chen Y, et al. Pharmacol Res. 2020 Sep;159:105007. doi: 10.1016/j.phrs.2020.105007. Epub 2020 Jun 17. Pharmacol Res. 2020. PMID: 32561477 Free article.

Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR.

Della Corte CM, Malapelle U, Vigliar E, Pepe F, Troncone G, Ciaramella V, Troiani T, Martinelli E, Belli V, Ciardiello F, Morgillo F. Della Corte CM, et al. Oncotarget. 2017 Apr 4;8(14):23020-23032. doi: 10.18632/oncotarget.15479. Oncotarget. 2017. PMID: 28416737 Free PMC article.

Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancer.

Nakagawa T, Takeuchi S, Yamada T, Nanjo S, Ishikawa D, Sano T, Kita K, Nakamura T, Matsumoto K, Suda K, Mitsudomi T, Sekido Y, Uenaka T, Yano S. Nakagawa T, et al. Mol Cancer Ther. 2012 Oct;11(10):2149-57. doi: 10.1158/1535-7163.MCT-12-0195. Epub 2012 Jul 25. Mol Cancer Ther. 2012. PMID: 22844075

244-MPT overcomes gefitinib resistance in non-small cell lung cancer cells.

Zhang Y, Yao K, Shi C, Jiang Y, Liu K, Zhao S, Chen H, Reddy K, Zhang C, Chang X, Ryu J, Bode AM, Dong Z, Dong Z. Zhang Y, et al. Oncotarget. 2015 Dec 29;6(42):44274-88. doi: 10.18632/oncotarget.6236. Oncotarget. 2015. PMID: 26517520 Free PMC article.

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