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Downregulation of topoisomerase IIbeta in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest.
Chikamori K, Hill JE, Grabowski DR, Zarkhin E, Grozav AG, Vaziri SA, Wang J, Gudkov AV, Rybicki LR, Bukowski RM, Yen A, Tanimoto M, Ganapathi MK, Ganapathi R. Chikamori K, et al. Among authors: rybicki lr. Leukemia. 2006 Oct;20(10):1809-18. doi: 10.1038/sj.leu.2404351. Epub 2006 Aug 17. Leukemia. 2006. PMID: 16932348
Sensitization of DNA damage-induced apoptosis by the proteasome inhibitor PS-341 is p53 dependent and involves target proteins 14-3-3sigma and survivin.
Vaziri SA, Hill J, Chikamori K, Grabowski DR, Takigawa N, Chawla-Sarkar M, Rybicki LR, Gudkov AV, Mekhail T, Bukowski RM, Ganapathi MK, Ganapathi R. Vaziri SA, et al. Among authors: rybicki lr. Mol Cancer Ther. 2005 Dec;4(12):1880-90. doi: 10.1158/1535-7163.MCT-05-0222. Mol Cancer Ther. 2005. PMID: 16373703