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4-Hydroxybenzyl modification of the highly teratogenic retinoid, 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-propen-1-yl]benzoic acid (TTNPB), yields a compound that induces apoptosis in breast cancer cells and shows reduced teratogenicity.
Chem Res Toxicol. 2011 Nov 21;24(11):1853-61. doi: 10.1021/tx200174n. Epub 2011 Oct 19.
Chem Res Toxicol. 2011.
PMID: 21939267
Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid.
Ahrens JM, Jones JD, Nieves NJ, Mitzey AM, DeLuca HF, Clagett-Dame M.
Ahrens JM, et al. Among authors: nieves nj.
PLoS One. 2017 Nov 28;12(11):e0188887. doi: 10.1371/journal.pone.0188887. eCollection 2017.
PLoS One. 2017.
PMID: 29182680
Free PMC article.
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Identification of a unique subset of 2-methylene-19-nor analogs of vitamin D with comedolytic activity in the rhino mouse.
Nieves NJ, Ahrens JM, Plum LA, DeLuca HF, Clagett-Dame M.
Nieves NJ, et al.
J Invest Dermatol. 2010 Oct;130(10):2359-67. doi: 10.1038/jid.2010.142. Epub 2010 Jun 10.
J Invest Dermatol. 2010.
PMID: 20535127
Free article.
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Inhibition of mammary tumor growth by a novel nontoxic retinoid: chemotherapeutic evaluation of a C-linked analog of 4-HPR-glucuronide.
Alshafie GA, Walker JR, Curley RW Jr, Clagett-Dame M, Highland MA, Nieves NJ, Stonerock LA, Abou-Issa H.
Alshafie GA, et al. Among authors: nieves nj.
Anticancer Res. 2005 May-Jun;25(3c):2391-8.
Anticancer Res. 2005.
PMID: 16082771
Free article.
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