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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 1
1981 5
1982 1
1983 3
1984 4
1985 3
1986 3
1987 9
1988 4
1989 7
1990 6
1991 8
1992 11
1993 8
1994 14
1995 7
1996 14
1997 14
1998 21
1999 16
2000 22
2001 17
2002 23
2003 30
2004 47
2005 45
2006 43
2007 61
2008 67
2009 94
2010 90
2011 111
2012 126
2013 158
2014 197
2015 205
2016 240
2017 242
2018 268
2019 376
2020 413
2021 454
2022 515
2023 486
2024 208

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4,173 results

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Page 1
N6-Methyladenosine Reader YTHDF1 Promotes ARHGEF2 Translation and RhoA Signaling in Colorectal Cancer.
Wang S, Gao S, Zeng Y, Zhu L, Mo Y, Wong CC, Bao Y, Su P, Zhai J, Wang L, Soares F, Xu X, Chen H, Hezaveh K, Ci X, He A, McGaha T, O'Brien C, Rottapel R, Kang W, Wu J, Zheng G, Cai Z, Yu J, He HH. Wang S, et al. Among authors: wu j. Gastroenterology. 2022 Apr;162(4):1183-1196. doi: 10.1053/j.gastro.2021.12.269. Epub 2021 Dec 28. Gastroenterology. 2022. PMID: 34968454 Free article.
BACKGROUND & AIMS: N6-methyladenosine (m(6)A) governs the fate of RNAs through m(6)A readers. Colorectal cancer (CRC) exhibits aberrant m(6)A modifications and expression of m(6)A regulators. However, how m(6)A readers interpret oncogenic …
BACKGROUND & AIMS: N6-methyladenosine (m(6)A) governs the fate of RNAs through m(6)A readers. Colorectal cancer (CRC) exhi …
HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice.
Zhang Y, Yang Y, Yang F, Liu X, Zhan P, Wu J, Wang X, Wang Z, Tang W, Sun Y, Zhang Y, Xu Q, Shang J, Zhen J, Liu M, Yi F. Zhang Y, et al. Among authors: wu j. Nat Commun. 2023 May 25;14(1):3007. doi: 10.1038/s41467-023-38771-4. Nat Commun. 2023. PMID: 37230975 Free PMC article.
Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the key HDAC isoforms and the underlying mechanism that are involved in G2/M arrest of TECs remain unclear. ...In vitro, knockdown or inhibition of H …
Renal tubular epithelial cells (TECs) play a key role in kidney fibrosis by mediating cycle arrest at G2/M. However, the key HDAC iso …
Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-κB/IL-6 signaling pathway.
Zheng Y, Li Y, Ran X, Wang D, Zheng X, Zhang M, Yu B, Sun Y, Wu J. Zheng Y, et al. Among authors: wu j. Cell Mol Life Sci. 2022 May 22;79(6):311. doi: 10.1007/s00018-022-04331-0. Cell Mol Life Sci. 2022. PMID: 35598196 Free PMC article.
The inflammatory state of macrophages is modified by epigenetic reprogramming. m(6)A RNA methylation is an epigenetic modification of RNAs. However, little is known about the potential roles and underlying mechanisms of m(6)A modification in macrophage inflammation. …
The inflammatory state of macrophages is modified by epigenetic reprogramming. m(6)A RNA methylation is an epigenetic modification of …
m(6) A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis.
Yang X, Bai Q, Chen W, Liang J, Wang F, Gu W, Liu L, Li Q, Chen Z, Zhou A, Long J, Tian H, Wu J, Ding X, Zhou N, Li M, Yang Y, Cai J. Yang X, et al. Among authors: wu j. Adv Sci (Weinh). 2023 Jul;10(20):e2206744. doi: 10.1002/advs.202206744. Epub 2023 May 12. Adv Sci (Weinh). 2023. PMID: 37171793 Free PMC article.
The importance of mRNA N6-methyladenosine (m(6) A) modification during tumor metastasis is controversial as it plays distinct roles in different biological contexts. Moreover, how cancer cell plasticity is shaped by m(6) A modification is interesting but remains unc …
The importance of mRNA N6-methyladenosine (m(6) A) modification during tumor metastasis is controversial as it plays distinct roles i …
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m(6)A-guided epigenetic inhibition of LYPD1.
Chen Y, Zhao Y, Chen J, Peng C, Zhang Y, Tong R, Cheng Q, Yang B, Feng X, Lu Y, Xie H, Zhou L, Wu J, Zheng S. Chen Y, et al. Among authors: wu j. Mol Cancer. 2020 Aug 10;19(1):123. doi: 10.1186/s12943-020-01239-w. Mol Cancer. 2020. PMID: 32772918 Free PMC article.
Functionally, ALKBH5 suppressed the proliferation and invasion capabilities of HCC cells in vitro and in vivo. Mechanistically, ALKBH5-mediated m(6)A demethylation led to a post-transcriptional inhibition of LY6/PLAUR Domain Containing 1 (LYPD1), which could be recognized …
Functionally, ALKBH5 suppressed the proliferation and invasion capabilities of HCC cells in vitro and in vivo. Mechanistically, ALKBH5-media …
Mycobacterial EST12 activates a RACK1-NLRP3-gasdermin D pyroptosis-IL-1β immune pathway.
Qu Z, Zhou J, Zhou Y, Xie Y, Jiang Y, Wu J, Luo Z, Liu G, Yin L, Zhang XL. Qu Z, et al. Among authors: wu j. Sci Adv. 2020 Oct 23;6(43):eaba4733. doi: 10.1126/sciadv.aba4733. Print 2020 Oct. Sci Adv. 2020. PMID: 33097533 Free PMC article.
However, macrophage pyroptosis-related proteins from Mycobacterium tuberculosis (M.tb) have largely gone unexplored. Here, we identified a cell pyroptosis-inducing protein, Rv1579c, named EST12, secreted from the M.tb H37Rv region of difference 3. ...An EST12-defici …
However, macrophage pyroptosis-related proteins from Mycobacterium tuberculosis (M.tb) have largely gone unexplored. Here, we identif …
RNA N(6)-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m(6)A-GLUT1-mTORC1 Axis and Is a Therapeutic Target.
Chen H, Gao S, Liu W, Wong CC, Wu J, Wu J, Liu D, Gou H, Kang W, Zhai J, Li C, Su H, Wang S, Soares F, Han J, He HH, Yu J. Chen H, et al. Among authors: wu j. Gastroenterology. 2021 Mar;160(4):1284-1300.e16. doi: 10.1053/j.gastro.2020.11.013. Epub 2020 Nov 18. Gastroenterology. 2021. PMID: 33217448 Free article.
BACKGROUND & AIMS: RNA N(6)-methyladenosine (m(6)A) modification has recently emerged as a new regulatory mechanism in cancer progression. ...Mechanistically, METTL3 directly induced the m(6)A-GLUT1-mTORC1 axis as identified by integrated m(6)A sequencing …
BACKGROUND & AIMS: RNA N(6)-methyladenosine (m(6)A) modification has recently emerged as a new regulatory mechanism in cancer pro …
N6-Methyladenosine Modification of ANLN Enhances Hepatocellular Carcinoma Bone Metastasis.
Zheng H, Cheng ZJ, Liang B, Wang ZG, Tao YP, Huang SY, Ni JS, Li HF, Yang L, Yuan SX, Wu J, Kawaguchi T, Samant H, Zhou WP, Xiang DM, Yang Y. Zheng H, et al. Among authors: wu j. Int J Biol Sci. 2023 Jan 22;19(4):1009-1023. doi: 10.7150/ijbs.73570. eCollection 2023. Int J Biol Sci. 2023. PMID: 36923927 Free PMC article.
Bones are categorized as the second most prevalent location of extra-hepatic metastasis in Hepatocellular Carcinoma (HCC), which is linked to an extremely poor prognosis due to limited therapeutic options. N(6)-methyladenosine (m(6)A) is a prominent modification involved i …
Bones are categorized as the second most prevalent location of extra-hepatic metastasis in Hepatocellular Carcinoma (HCC), which is linked t …
N6-Methyladenosine: A Potential Breakthrough for Human Cancer.
Liu L, Wang Y, Wu J, Liu J, Qin Z, Fan H. Liu L, et al. Among authors: wu j. Mol Ther Nucleic Acids. 2020 Mar 6;19:804-813. doi: 10.1016/j.omtn.2019.12.013. Epub 2019 Dec 20. Mol Ther Nucleic Acids. 2020. PMID: 31958696 Free PMC article. Review.
As a dynamic and reversible modification, m(6)A is catalyzed by "writers" (RNA methyltransferases), removed by "erasers" (demethylases), and interacts with "readers" (m(6)A-binding proteins). With more advanced technology applied to research, the molecular mechanism …
As a dynamic and reversible modification, m(6)A is catalyzed by "writers" (RNA methyltransferases), removed by "erasers" (demethylase …
Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m(6)A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling.
Liu BH, Tu Y, Ni GX, Yan J, Yue L, Li ZL, Wu JJ, Cao YT, Wan ZY, Sun W, Wan YG. Liu BH, et al. Among authors: wu jj. Front Pharmacol. 2021 Jul 15;12:667644. doi: 10.3389/fphar.2021.667644. eCollection 2021. Front Pharmacol. 2021. PMID: 34335245 Free PMC article.
Regulation of the PTEN/PI3K/Akt pathway is an effective strategy for improving podocyte damage in DKD. Previous research has also shown that N6-methyladenosine (m(6)A) modification is involved in DKD and that m(6)A-modified PTEN regulates the PI3K/Akt pathway. ...TF …
Regulation of the PTEN/PI3K/Akt pathway is an effective strategy for improving podocyte damage in DKD. Previous research has also shown that …
4,173 results