Radiotherapy of Prostate Carcinoma: A Comparison of the Predictive Role of EAU Versus NCCN Risk Stratification Systems

Anticancer Res. 2020 Aug;40(8):4413-4418. doi: 10.21873/anticanres.14446.

Abstract

Background/aim: To compare the predictive efficacy of National Comprehensive Cancer Network (NCCN) and European Association of Urology (EAU) risk stratification systems in radiotherapy of prostate cancer.

Patients and methods: One-thousand-nine-hundred-nine patients treated with definitive (1,074), adjuvant (381), and salvage radiotherapy (454) were analysed.

Results: Both systems significantly predicted biochemical-relapse-free-survival, metastasis-free-survival, and disease-free-survival, while only the NCCN system correlated with local-control in the definitive radiotherapy group. In the adjuvant setting, both systems failed to predict all outcomes. In the salvage setting, only the NCCN system significantly predicted biochemical-relapse-free-survival, metastasis-free-survival and disease-free-survival.

Conclusion: This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy.

Keywords: EAU; NCCN; Risk stratification systems; prostate neoplasms; radiotherapy.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Humans
  • Kallikreins / metabolism
  • Male
  • Multicenter Studies as Topic
  • Observational Studies as Topic
  • Prostate-Specific Antigen / metabolism
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / radiotherapy*
  • Radiotherapy Dosage
  • Radiotherapy, Adjuvant / statistics & numerical data*
  • Retrospective Studies
  • Risk Assessment
  • Salvage Therapy / statistics & numerical data*
  • Survival Analysis
  • Treatment Outcome

Substances

  • KLK3 protein, human
  • Kallikreins
  • Prostate-Specific Antigen