Abstract
Analogues related to 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 (ED-71) (2), 26,27-dimethyl ED-71 (3) and 26,27-diethyl ED-71 (4), were synthesized from lithocholic acid (5). In the study of the preventive effects of these analogues and ED-71 (2) on bone mineral loss in ovariectomized rats, 26,27-dimethyl ED-71 (3) showed the most potent activity.
MeSH terms
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Animals
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Bone Density / drug effects*
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Calcitriol / analogs & derivatives*
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Calcitriol / chemical synthesis*
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Calcitriol / chemistry
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Calcitriol / therapeutic use
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Cattle
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Female
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Indicators and Reagents
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Lithocholic Acid
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Molecular Structure
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Osteoporosis / prevention & control*
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Ovariectomy*
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Rats
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Rats, Wistar
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Receptors, Calcitriol / metabolism
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Structure-Activity Relationship
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Thymus Gland / metabolism
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Vitamin D / analogs & derivatives
Substances
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Indicators and Reagents
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Receptors, Calcitriol
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Vitamin D
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Lithocholic Acid
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Calcitriol
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eldecalcitol