Abstract
We identified a novel heterodimeric protein, lipophilin AC, in human tears. One of its components, lipophilin A (69 residues; mass, 7575.1; pI, 9.47) was homologous to the C1 and C2 components of prostatein ('estramustine-binding protein'), the major secreted protein of rat prostate. Human lipophilin C (77 residues; mass, 8854.1; pI, 4.94) was homologous to the rat prostatein C3 component and to human mammaglobin, a protein overexpressed in some mammary carcinomas. Tear lipophilins A and C expand the roster of human uteroglobin superfamily members and provide models for exploring these typically steroid-regulated and steroid-binding molecules.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Chromatography, High Pressure Liquid
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Dimerization
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Humans
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Mammaglobin B
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Molecular Sequence Data
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Molecular Weight
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Myelin Proteins / analysis
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Myelin Proteins / chemistry*
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Myelin Proteins / isolation & purification
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Peptides / chemistry
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Peptides / metabolism
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Protein Binding
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Protein Conformation
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Proteolipids / analysis
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Proteolipids / chemistry*
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Proteolipids / isolation & purification
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Secretoglobins
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Sequence Analysis
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Sequence Homology, Amino Acid
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Tears / chemistry*
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Uteroglobin
Substances
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Mammaglobin B
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Myelin Proteins
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Peptides
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Proteolipids
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SCGB1D1 protein, human
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SCGB2A1 protein, human
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Secretoglobins
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Uteroglobin