Abstract
This review paper will focus on the molecular biological, biochemical and biophysical aspects of the following three efflux pumps: P-glycoprotein (Pgp), Multidrug Resistance Protein (MRP) and Lung cancer Resistance-related Protein. Since suppression of the function of these pumps has clinical implications, novel approaches developed in our laboratory for blocking the function of Pgp and MRP are also discussed. The second part of this review will summarize the clinical significance and the results of clinical trials designed to suppress the effects of these efflux pumps.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / physiology*
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ATP-Binding Cassette Transporters / physiology*
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Animals
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Antineoplastic Agents / pharmacokinetics
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Antineoplastic Agents / pharmacology*
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Drug Resistance, Multiple / physiology*
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Drug Resistance, Neoplasm / physiology*
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Humans
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Mice
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Multidrug Resistance-Associated Proteins
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Neoplasm Proteins / physiology*
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Vault Ribonucleoprotein Particles*
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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ATP-Binding Cassette Transporters
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Antineoplastic Agents
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Multidrug Resistance-Associated Proteins
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Neoplasm Proteins
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Vault Ribonucleoprotein Particles
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major vault protein