An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs

T Inoue; G Chen; K Nakamae; A S Hoffman

doi:10.1016/s0168-3659(97)00172-7

An AB block copolymer of oligo(methyl methacrylate) and poly(acrylic acid) for micellar delivery of hydrophobic drugs

J Control Release. 1998 Feb 12;51(2-3):221-9. doi: 10.1016/s0168-3659(97)00172-7.

Authors

T Inoue¹, G Chen, K Nakamae, A S Hoffman

Affiliation

¹ Bioengineering Department, University of Washington, Seattle 98195, USA.

PMID: 9685920
DOI: 10.1016/s0168-3659(97)00172-7

Abstract

An AB block copolymer of oligo(methyl methacrylate) (oMMA) and poly(acrylic acid) (PAAc) has been synthesized. The block copolymer forms micelles in an aqueous medium, as confirmed by a fluorescence probe technique using pyrene. Doxorubicin hydrochloride was incorporated into the micelle and the release profile of doxorubicin hydrochloride was investigated. Slow and prolonged release of doxorubicin hydrochloride from the micelle was observed. The AB block copolymer micelle can be useful for prolonged mucosal drug delivery of hydrophobic drugs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acrylic Resins / chemistry*
Antibiotics, Antineoplastic / chemistry
Antibiotics, Antineoplastic / metabolism
Delayed-Action Preparations
Doxorubicin / chemistry
Doxorubicin / metabolism
Drug Delivery Systems*
Fluorescent Dyes / analysis
Micelles
Polymethyl Methacrylate / chemistry*
Pyrenes / analysis
Spectrometry, Fluorescence

Substances

Acrylic Resins
Antibiotics, Antineoplastic
Delayed-Action Preparations
Fluorescent Dyes
Micelles
Pyrenes
carbopol 940
Doxorubicin
Polymethyl Methacrylate
pyrene