[Expression of proliferation markers PCNA and MIB 1 in verrucous squamous epithelial carcinoma of the oral cavity]

D Theegarten; A Barfuss; N C Gellrich; S Philippou

doi:10.1007/BF03043532

[Expression of proliferation markers PCNA and MIB 1 in verrucous squamous epithelial carcinoma of the oral cavity]

Mund Kiefer Gesichtschir. 1997 May;1(3):133-6. doi: 10.1007/BF03043532.

[Article in German]

Authors

D Theegarten¹, A Barfuss, N C Gellrich, S Philippou

Affiliation

¹ Abteilung für Pathologie, Ruhr-Universität, Bochum.

PMID: 9410620
DOI: 10.1007/BF03043532

Abstract

Expression of proliferation markers PCNA and MIB 1 was evaluated in 17 verrucous carcinomas and in five cases of normal squamous epithelium of the oral cavity. Immunohistochemistry revealed no significant differences in the proliferative activities. Highest expression was seen in the basal zones. Proliferative activity in more than 26% of cells is no longer compatible with verrucous carcinoma, but favours the diagnosis of squamous cell carcinoma.

Publication types

English Abstract

MeSH terms

Aged
Aged, 80 and over
Antigens, Nuclear
Biomarkers, Tumor / analysis*
Carcinoma, Verrucous / pathology*
Cell Division / physiology*
Female
Humans
Ki-67 Antigen
Male
Middle Aged
Mouth Mucosa / pathology
Mouth Neoplasms / pathology*
Neoplasm Staging
Nuclear Proteins / analysis*
Proliferating Cell Nuclear Antigen / analysis*

Substances

Antigens, Nuclear
Biomarkers, Tumor
Ki-67 Antigen
Nuclear Proteins
Proliferating Cell Nuclear Antigen