Abstract
Two new (3 and 5), as well as three known (1, 2, and 4), polyynes were isolated from Devil's Club (Oplopanax horridus; Araliaceae), a medicinal plant of North America. The structures were established by 1H and 13C NMR. The absolute configurations of 2 and 5 were determined by application of Mosher's method. All the polyynes exhibited significant anti-Candida, antibacterial, and antimycobacterial activity, with an ability to kill Mycobacterium tuberculosis and isoniazid-resistant Mycobacterium avium at 10 micrograms/disk in a disk diffusion assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antitubercular Agents / pharmacology
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Drug Resistance, Microbial
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Isoniazid / pharmacology
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Microbial Sensitivity Tests
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Mycobacterium / drug effects*
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Mycobacterium avium / drug effects
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Mycobacterium tuberculosis / drug effects
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Plant Epidermis / chemistry
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Plants, Medicinal / chemistry*
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Polyenes / isolation & purification*
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Polyenes / pharmacology
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Spectrophotometry, Infrared
Substances
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Anti-Bacterial Agents
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Antitubercular Agents
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Polyenes
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Isoniazid