Abstract
A specific receptor for 1,25-dihydroxyvitamin D has been demonstrated in a cultured human breast cancer cell line. This is the first such demonstration in any cancer cell. It may explain the high incidence of metastatic bone destruction and hypercalcaemia in this common malignancy, and the limited success of other steroid-receptor assays in predicting the response of breast cancer to therapy.
MeSH terms
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Binding, Competitive
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Bone Neoplasms / etiology
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Bone Neoplasms / secondary
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Breast / ultrastructure
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology
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Calcium / metabolism
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Cell Line
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Cells, Cultured
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Cytosol / metabolism*
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Dihydroxycholecalciferols / metabolism*
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Female
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Humans
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Hydroxycholecalciferols / metabolism*
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Hypercalcemia / etiology
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Receptors, Steroid / isolation & purification*
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Receptors, Steroid / metabolism
Substances
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Dihydroxycholecalciferols
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Hydroxycholecalciferols
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Receptors, Steroid
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Calcium