Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22

J D Knox; D R Boreham; J A Walker; D P Morrison; L M Matrisian; R B Nagle; G T Bowden

doi:10.1159/000134181

Mapping of the metalloproteinase gene matrilysin (MMP7) to human chromosome 11q21-->q22

Cytogenet Cell Genet. 1996;72(2-3):179-82. doi: 10.1159/000134181.

Authors

J D Knox¹, D R Boreham, J A Walker, D P Morrison, L M Matrisian, R B Nagle, G T Bowden

Affiliation

¹ Department of Pathology, University of Arizona, Tucson, USA.

PMID: 8978768
DOI: 10.1159/000134181

Abstract

The matrix metalloproteinase, matrilysin, is thought to play an important role in the early steps of tumor progression. We determined the chromosome location of the matrilysin gene (MMP7) by Southern and PCR analysis of two different panels of somatic cell hybrids and in situ hybridization of metaphase chromosomes. Matrilysin maps to the region, 11q21-->q22, adding MMP7 to the cluster of matrix metalloproteinase genes that have already mapped to this region.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Base Sequence
Chromosome Mapping*
Chromosomes, Human, Pair 11 / genetics*
Humans
Matrix Metalloproteinase 7
Metalloendopeptidases / genetics*
Molecular Sequence Data
Polymerase Chain Reaction

Substances

Metalloendopeptidases
Matrix Metalloproteinase 7