Abstract
When pregnant mice were given small doses of teratogens (cytosine arabinoside, mitomycin C, or busulfan) that did not induce anomalies of any other organs, a high incidence of carpal and tarsal bone anomalies still occurred. The carpal and tarsal bones may be used as a sensitive target for teratogenicity testing.
MeSH terms
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Abnormalities, Drug-Induced / etiology*
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Animals
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Antineoplastic Agents / toxicity*
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Busulfan / toxicity*
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Carpal Bones / abnormalities*
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Cytarabine / toxicity*
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Dose-Response Relationship, Drug
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Female
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Mice
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Mitomycin / toxicity*
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Pregnancy
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Tarsal Bones / abnormalities*
Substances
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Antineoplastic Agents
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Cytarabine
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Mitomycin
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Busulfan