Carpal and tarsal bone development is highly sensitive to three antiproliferative teratogens in mice

Reprod Toxicol. 1996 Nov-Dec;10(6):485-9. doi: 10.1016/s0890-6238(96)00135-9.

Abstract

When pregnant mice were given small doses of teratogens (cytosine arabinoside, mitomycin C, or busulfan) that did not induce anomalies of any other organs, a high incidence of carpal and tarsal bone anomalies still occurred. The carpal and tarsal bones may be used as a sensitive target for teratogenicity testing.

Publication types

  • Comparative Study

MeSH terms

  • Abnormalities, Drug-Induced / etiology*
  • Animals
  • Antineoplastic Agents / toxicity*
  • Busulfan / toxicity*
  • Carpal Bones / abnormalities*
  • Cytarabine / toxicity*
  • Dose-Response Relationship, Drug
  • Female
  • Mice
  • Mitomycin / toxicity*
  • Pregnancy
  • Tarsal Bones / abnormalities*

Substances

  • Antineoplastic Agents
  • Cytarabine
  • Mitomycin
  • Busulfan