Scavenger receptors are cell-surface proteins expressed by mammalian monocytes and macrophages and by invertebrate hemocytes, among other cell types. They exhibit distinctive ligand-binding properties, recognizing a wide range of ligands that include microbial surface constituents and intact microbes. The ligand-binding properties and expression patterns of these receptors suggest that they may function in one or more host-defense-related processes. Significant advances in scavenger receptor biology have recently been reported, including the identification of several new scavenger receptor genes.