Atypical fibroxanthoma is a cutaneous soft tissue tumor that may mimic squamous cell carcinoma and melanoma on clinical and histologic examination. Immunohistochemical stains for cytokeratin, S100 protein, and vimentin may be helpful in differentiating atypical fibroxanthoma from the latter two diagnoses. We report a patient with atypical fibroxanthoma of the cheek who underwent successful local excision. The clinical and laboratory features of this neoplasm are reviewed.