Abstract
An unusual sulfated heteropolysaccharide containing uronic acids, previously isolated from the red alga Schizymenia dubyi, was studied in vitro for its effect on asynchronous cells of a human non-small-cell-bronchopulmonary carcinoma line (NSCLC-N6). Cell growth appeared to be inhibited in the G1 phase of the cell cycle, and kinetic studies in pretreated cells showed that this growth arrest was irreversible. These events are related to a terminal maturation induction.
MeSH terms
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Antineoplastic Agents / pharmacology*
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Bronchial Neoplasms / drug therapy*
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Bronchial Neoplasms / pathology
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Carcinoma, Non-Small-Cell Lung / drug therapy*
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Carcinoma, Non-Small-Cell Lung / pathology
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Cell Division / drug effects
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DNA, Neoplasm / analysis
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Fluorescence
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Humans
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / pathology
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Polysaccharides / pharmacology*
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Rhodophyta / chemistry
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Sulfates / pharmacology
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Tumor Cells, Cultured / drug effects
Substances
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Antineoplastic Agents
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DNA, Neoplasm
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Polysaccharides
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Sulfates