Abstract
Immunohistochemistry and RT-PCR of basic fibroblast growth factor (bFGF) and one of its receptors (FGFR-I) were performed in pituitary adenomas. Sixty percent of pituitary adenomas showed strong or moderate immunoreactivity to bFGF. The immunoreactivity for FGFR-I in tumor tissues showed positive correlation to that for bFGF (X2 = 6.176, P = 0.0456). Basic FGF-positive cells consisted of pituitary adenoma cells as well as folliculostellate cells and, their distribution was heterogeneous. Expressions of bFGF and FGFR-I were not related to cell proliferation of pituitary adenomas or hormones produced, suggesting that bFGF plays some role other than progression of pituitary adenomas.
MeSH terms
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Adenoma / immunology
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Adenoma / metabolism*
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Adult
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Aged
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Antigens, Neoplasm / immunology
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Antigens, Neoplasm / metabolism
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Base Sequence
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Female
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Fibroblast Growth Factor 2 / biosynthesis
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Fibroblast Growth Factor 2 / immunology
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Fibroblast Growth Factor 2 / metabolism*
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Molecular Sequence Data
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Nuclear Proteins / immunology
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Nuclear Proteins / metabolism
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Pituitary Neoplasms / immunology
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Pituitary Neoplasms / metabolism*
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Polymerase Chain Reaction
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Proliferating Cell Nuclear Antigen
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RNA, Messenger / biosynthesis
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Receptors, Fibroblast Growth Factor / biosynthesis
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Receptors, Fibroblast Growth Factor / immunology
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Receptors, Fibroblast Growth Factor / metabolism*
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S100 Proteins / immunology
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S100 Proteins / metabolism
Substances
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Antigens, Neoplasm
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Nuclear Proteins
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Proliferating Cell Nuclear Antigen
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RNA, Messenger
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Receptors, Fibroblast Growth Factor
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S100 Proteins
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Fibroblast Growth Factor 2