Abstract
Inhibitors of 5 alpha-reductase may be effective in the treatment of 5 alpha-dihydrotestosterone-dependent abnormalities, such as benign prostate hyperplasia, prostate cancer and certain skin diseases. The green tea catechins, (-)epigallocatechin-3-gallate and (-)epicatechin-3-gallate, but not (-)epicatechin and (-)epigallocatechin, are potent inhibitors of type 1 but not type 2 5 alpha-reductase. (-)Epigallocatechin-3-gallate also inhibits accessory sex gland growth in the rat. These results suggest that certain tea gallates can regulate androgen action in target organs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3-Oxo-5-alpha-Steroid 4-Dehydrogenase / metabolism
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5-alpha Reductase Inhibitors*
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Animals
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Catechin / analogs & derivatives*
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Catechin / pharmacology
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Cell Line
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Enzyme Inhibitors / pharmacology*
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Genitalia, Male / drug effects
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Genitalia, Male / growth & development
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Humans
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Isoenzymes / antagonists & inhibitors
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Kinetics
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Male
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Microsomes / enzymology*
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Microsomes, Liver / enzymology*
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Prostate / drug effects
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Prostate / enzymology
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Prostate / growth & development
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Rats
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Rats, Sprague-Dawley
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Recombinant Proteins / antagonists & inhibitors
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Seminal Vesicles / drug effects
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Seminal Vesicles / growth & development
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Structure-Activity Relationship
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Tea*
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Transfection
Substances
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5-alpha Reductase Inhibitors
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Enzyme Inhibitors
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Isoenzymes
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Recombinant Proteins
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Tea
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Catechin
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epicatechin gallate
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epigallocatechin gallate
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3-Oxo-5-alpha-Steroid 4-Dehydrogenase