The pathogenesis of cancer metastasis

Nature. 1980 Jan 10;283(5743):139-46. doi: 10.1038/283139a0.

Abstract

Metastases do not result from random survival of cells released from the primary tumour but from the selective growth of specialised subpopulations of highly metastatic cells endowed with specific properties that befit them to complete each step of the metastatic process.

Publication types

  • Review

MeSH terms

  • Animals
  • Basement Membrane / physiology
  • Cell Adhesion
  • Cell Division
  • Cell Membrane / physiology
  • Cell Movement
  • Endothelium / pathology
  • Humans
  • Immunity
  • Lung Neoplasms / pathology
  • Melanoma / pathology
  • Neoplasm Metastasis*
  • Neoplasms / immunology
  • Neoplasms / pathology*
  • Neoplasms, Experimental / pathology
  • Selection, Genetic