The Role of CLEC-2 and Its Ligands in Thromboinflammation

Front Immunol. 2021 Jun 9:12:688643. doi: 10.3389/fimmu.2021.688643. eCollection 2021.

Abstract

C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years. CLEC-2 is involved in platelet activation, tumor cell metastasis, separation of blood/lymphatic vessels, and cerebrovascular patterning during embryonic development. In this review, we have discussed the role of CLEC-2 in thromboinflammation, and focused on the recent research.

Keywords: CLEC-2; inflammation; podoplanin; thromboinflammation; thrombosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Blood Coagulation* / drug effects
  • Fibrinolytic Agents / therapeutic use
  • Humans
  • Inflammation / blood
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Inflammation / metabolism*
  • Inflammation Mediators / metabolism*
  • Lectins, C-Type / antagonists & inhibitors
  • Lectins, C-Type / metabolism*
  • Ligands
  • Membrane Glycoproteins / metabolism
  • Signal Transduction
  • Thrombosis / blood
  • Thrombosis / drug therapy
  • Thrombosis / immunology
  • Thrombosis / metabolism*

Substances

  • Anti-Inflammatory Agents
  • CLEC1B protein, human
  • Fibrinolytic Agents
  • Inflammation Mediators
  • Lectins, C-Type
  • Ligands
  • Membrane Glycoproteins
  • PDPN protein, human