Abstract
C-type lectin-like receptor 2 (CLEC-2, also known as CLEC-1b) is expressed on platelets, Kupffer cells and other immune cells, and binds to various ligands including the mucin-like protein podoplanin (PDPN). The role of CLEC-2 in infection and immunity has become increasingly evident in recent years. CLEC-2 is involved in platelet activation, tumor cell metastasis, separation of blood/lymphatic vessels, and cerebrovascular patterning during embryonic development. In this review, we have discussed the role of CLEC-2 in thromboinflammation, and focused on the recent research.
Keywords:
CLEC-2; inflammation; podoplanin; thromboinflammation; thrombosis.
Copyright © 2021 Meng, Luo and Liu.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Inflammatory Agents / therapeutic use
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Blood Coagulation* / drug effects
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Fibrinolytic Agents / therapeutic use
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Humans
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Inflammation / blood
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Inflammation / drug therapy
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Inflammation / immunology
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Inflammation / metabolism*
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Inflammation Mediators / metabolism*
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Lectins, C-Type / antagonists & inhibitors
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Lectins, C-Type / metabolism*
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Ligands
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Membrane Glycoproteins / metabolism
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Signal Transduction
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Thrombosis / blood
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Thrombosis / drug therapy
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Thrombosis / immunology
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Thrombosis / metabolism*
Substances
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Anti-Inflammatory Agents
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CLEC1B protein, human
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Fibrinolytic Agents
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Inflammation Mediators
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Lectins, C-Type
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Ligands
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Membrane Glycoproteins
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PDPN protein, human